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Key mutation sites in the SARS-CoV-2 spike protein modulate antibody and ACE2 affinity An allosteric center or site is one where a molecule other than the substrate to the protein can bind, altering the conformation of the protein. A paper recently uploaded to the preprint server bioRxiv* by researchers at Chapman University in California (Feb 22nd, 2021) utilized computational methods to screen severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mutants for affinity with the angiotensin-converting enzyme 2 (ACE2) receptor and monoclonal antibodies REG10987 and REG10933. The analysi...

Corticosteroid receptor inhibitor shows anti-SARS-CoV-2 activity in vivo Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of the coronavirus disease 2019 (COVID-19) pandemic. To date, SARS-CoV-2 has infected over 112 million people and has been responsible for over 2.48 million deaths. While vaccines against SARS-CoV-2 are being administered globally, treatment options for those infected are still limited. A team of researchers examined PT150, which is an allosteric modulator of androgen and glucocorticoid receptors, to assess whether it had any antiviral ac...

UK and South African SARS-CoV-2 variants show higher binding affinity to host cell receptor Public health officials are concerned over new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants emerging in various parts of the world. The B.1.1.7 variant was first found in the United Kingdom and found to have the N501Y mutation that allows it to have a faster transmission rate than previous strains. The B.1.351 variant was detected in South Africa and also has the N501Y genetic mutation observed in B.1.1.7. However, scientists are also concerned over two other genetic mutations ...

Household odorant smell tests could help detect COVID-19, say study Some of the most notable symptoms of coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), are hyposmia and anosmia. Hyposmia is the partial loss of smell, and anosmia is the complete loss of smell. Along with the loss of smell is the loss of taste, also known as ageusia, fever, cough, headache, and difficulty of breathing. With the skyrocketing number of cases globally, it is important to find easy, cost-effective, and fast screening tests. Researchers at the Weizman...

New data from researchers led by Majid Kazemian from Purdue University refutes claims from recent studies suggesting the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) could create a host-virus chimeric RNA. Their team found SARS-CoV-2 does not combine with the human genome.