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How SARS-CoV-2 enters the central nervous system The central nervous system (CNS) is highly protected in the human body. Yet, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) invades the CNS, causing profound clinical complications. How is the CNS involved in a respiratory virus infection? To understand this, researchers Ruqaiyyah Siddiqui, Mohammad Ridwane Mungroo and Naveed Ahmed Khan reviewed reported case studies and identified potential brain regions that may be affected by the SARS-CoV-2 and explored the virus's possible entry route into the brain to identify its pathoge...

Mink-derived SARS-CoV-2 mutations reduce antibody effectiveness The ongoing coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is thought to be a disease originally occurring in animals but transmitted across the species barrier to human beings, probably through an intermediate host. Following human infection, the virus has been shown to transmit to some pet and farm animals, where it then mutates. A new preprint research paper posted to the bioRxiv* server shows that these mutations disrupt inhibition by neutralizing ant...

Researchers in France report impaired neutralization of two new SARS-CoV-2 variants by antibodies induced by vaccination or natural infection.

As the exact zoonotic origin of SARS-CoV-2 remains unresolved, scientists at the Francis Crick Institute in London, UK, explored the structure and binding properties of a Pangolin coronavirus spike glycoprotein to see if it could shed light on the evolution of SARS-CoV-2.

Now, a new preprint research paper posted to the bioRxiv server reports the development of a modified mouse model that allows productive SARS-CoV-2 infection of the mouse lungs, as well as the exploration of type I and III interferon responses in this condition.