How SARS-CoV-2 enters the central nervous system The central nervous system (CNS) is highly protected in the human body. Yet, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) invades the CNS, causing profound clinical complications. How is the CNS involved in a respiratory virus infection? To understand this, researchers Ruqaiyyah Siddiqui, Mohammad Ridwane Mungroo and Naveed Ahmed Khan reviewed reported case studies and identified potential brain regions that may be affected by the SARS-CoV-2 and explored the virus's possible entry route into the brain to identify its pathogenicity. In a recent review in the medical journal Hospital Practice, the team discussed the related clinical cases, symptoms, and targets.