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Computationally designed peptide blocks the entry of SARS-CoV, SARS-CoV-2, and MERS-CoV

Computationally designed peptide blocks the entry of SARS-CoV, SARS-CoV-2, and MERS-CoV
It is essential to face some grim facts about the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pathogen. The ongoing COVID-19 (coronavirus disease 2019) pandemic, started in December 2019, may last for many years. SARS-CoV-2, the causative agent of COVID-19, is the seventh member of the
Coronaviridae family known to infect humans.
The SARS-CoV and MERS-CoV (Middle East respiratory syndrome coronavirus), two other members of this family, are the causative agents of the recent outbreaks of the SARS and MERS epidemics. Despite the two-decades-long interaction with these viruses, there is no therapeutic solution against the SARS, COVID-19, and MERS; only supportive care.

Ramya-dwivedi , National-institute-of-technology , Research-foundation , Middle-east , National-institute , Mers-cov , Ars , Ars-cov-2 , Oronavirus , Oronavirus-disease-covid-19 , Rugs , Andemic

Researchers identify SARS-CoV-2 antiviral compounds using protein assay

During the process of SARS-CoV-2 infection, once the virus penetrates the host cell, two open reading frames, ORF1a and ORF1ab, are translated. ORF1ab is responsible for the production of 16 nonstructural proteins (nsp). Several viral proteases such as 3CLpro and PLpro (papain-like protease) produce 1-16 nsps. A new study has been published in bioRxiv* preprint server, which deals with identifying drugs that are effective as PLpro inhibitors.

Priyom-bose , World-health-organization , Drug-administration , Francis-crick-institute , Small-molecule-inhibitors , Image-credit , Middle-east , Emergency-use-authorization , High-throughput-screening , Francis-crick , Coronavirus-disease-covid-19

New polypeptide could provide universal protection against coronaviruses

New polypeptide could provide universal protection against coronaviruses
Researchers in the United States have developed an inhibitor of the spike protein found on the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that limits its formation in host human cells that would otherwise be the source of newly generated virions.
The SARS-CoV-2 virus is the agent responsible for the ongoing coronavirus disease 2019 (COVID-19) pandemic and the spike protein is the main structure the virus relies on for host cell entry.
Importantly, the inhibitor was effective against the spike proteins of other coronaviruses, including SARS-CoV-1 and Middle East respiratory syndrome CoV (MERS-CoV).

China , Houston , Texas , United-states , Wuhan , Hubei , Baylor-college-of-medicine , Jianpeng-ma , Sally-robertson , Middle-east , Baylor-college , High-potency-polypeptide-based-interference

Chimeric vaccines may provide universal protection against viruses like SARS-CoV-2

Researchers in the United States have developed “chimeric” vaccines that provided cross-protection against different strains of sarbecovirus in mice, including the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that causes coronavirus disease 2019 (COVID-19).

Wuhan , Hubei , China , South-africa , United-states , South-african , David-martinez , Sally-robertson , Pfizer , University-of-north-carolina-at-chapel-hill , Middle-east , North-carolina

Study addresses glycosylation concerns in SARS-CoV-2 vaccine design

Study addresses glycosylation concerns in SARS-CoV-2 vaccine design
An international team of researchers has found that glycosylation patterns are conserved across the native spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent that causes coronavirus disease 2019 (COVID-19) – and the recombinant spike proteins made in laboratories for use in vaccines.
The spike protein, which SARS-CoV-2 uses to bind to and infect cells, is the main target of neutralizing antibodies following natural infection with the virus or vaccination.
A central tenet in vaccine design is the presentation of native-like antigens that will induce protective immunity.
"The abundance of N-linked glycans across the SARS-CoV-2 spike protein is a potential source of heterogeneity between the many different vaccine candidates under investigation," says Max Crispin from the University of Southampton in the UK and colleagues.

China , United-kingdom , Wuhan , Hubei , Texas , United-states , Max-crispin , Sally-robertson , University-of-southampton , Coronavirus-disease-covid-19 , Glycosylation , Sars

Newly-discovered bat coronavirus 94.5% identical to SARS-CoV-2

Researchers in China and Australia have reported the discovery of novel bat coronaviruses that further reveal the diversity and complex evolutionary history of these viruses.

Australia , Philippines , Japan , Thailand , Cambodia , China , Laos , Vietnam , Republic-of , Wuhan , Hubei , Lao

Early Release - Low-Level Middle East Respiratory Coronavirus Syndrome among Camel Handlers, Kenya, 2019 - Volume 27, Number 4—April 2021 - Emerging Infectious Diseases journal

9). Our findings are limited by the high C
t values ( 35) of all cases, a level which some experts might not consider to be positive. However, because these patients had C
t values 40 for 3 distinct MERS-CoV genes, we feel confident that these are unlikely to be false positive results. Researchers have observed low upper respiratory tract RNA concentrations in asymptomatic patients and contacts of MERS-CoV patients (
14). In contrast to studies conducted in the Middle East, we found no evidence of human-to-human transmission; a total of 20 household members of the 3 patients tested negative for MERS-CoV before and after their household member’s diagnosis. However, we might have missed some infections that occurred between follow-up visits. Furthermore, not all household members were enrolled in the study. In addition, serologic assessment of MERS-CoV T-cell responses might detect mild and asymptomatic MERS-CoV cases (

United-states , Nairobi , Nairobi-area , Kenya , Saudi-arabia , Marsabit , Eastern , America , Kenya-medical-research-institute-nairobi , Division-of-global-health-protection , Global-health

Scientists study seven human coronavirus envelope proteins using topology prediction and molecular modeling

A new study by researchers at the University of the Western Cape aimed to determine why some coronaviruses are more virulent than others. The team speculates that the increased flexibility of the PDZ-binding motif (PBM) of SARS-CoV, MERS-CoV, and SARS22 CoV-2 to be more flexible than the PBM of hCoVs 229E, NL63, OC43, and HKU1.

United-states , India , Brazil , Angela-betsaidab-laguipo , University-of-the-western-cape , Angela-betsaida , Middle-east , Western-cape , Image-credit , Corona-virus , Coronavirus-disease-covid-19

Researchers report zoonotic spillover of adapted SARS-CoV-2 from minks to humans

Researchers report zoonotic spillover of adapted SARS-CoV-2 from minks to humans
In a recent report made available on
bioRxiv* preprint server, researchers from Poland and Finland reveal a spillover event of mink-adapted severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from farmed mink to humans after an extensive adaptation process.
st century (after SARS-CoV and MERS-CoV viruses).
And while mass vaccination activities against COVID-19 are currently underway on a global level, we are still not yet sure how this pandemic (and its causative virus) will end. In other words, highly touted concepts of herd immunity and viral eradication are increasingly seen as unrealistic when prevalence, genetic diversity and pervasive animal reservoirs are taken into account.

Finland , Netherlands , Denmark , Poland , Lukasz-rabalski , University-of-gdansk , National-veterinary-research-institute , Intercollegiate-faculty , Medical-university , Northern-poland , Coronavirus-disease-covid-19 , Pandemic

Silay City celebrates Women's Month

SunStar
Silay City celebrates Women's Month
NEGROS. Silay City Councilor Lyndon Bernardo gives a certificate of appreciation to former Bacolod City councilor Jocelle Sigue who served as their guest speaker during the celebration of International Women's Month. (Contributed photo)
NEGROS. Vice Mayor Tom Ledesma, Dr. Sedie Ramos, and Councilor Lyndon Bernardo. (Contributed photo)
NEGROS. Silay City Mayor Mark Andrew Golez with a fellow, Vice Mayor Tom Ledesma and Councilor Lyndon Bernardo. (Contributed photo)
NEGROS. The International Women's Month celebration in Silay City on March 9, 2021. (Contributed photo)
NEGROS. Dr. Regina Buenaflor (center) receives her plaque of appreciation from Vice Mayor Ledesma and Councilor Bernardo. (Contributed photo)

Silay , Philippines , Bacolod-city , Bacolod , Silay-city , Dennis-velez , Andrew-penuela , Tom-ledesma , Jocelle-sigue , Lyndon-bernardo , Teresita-lopez-jalandoni , Regina-buenaflor