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This funding will be used to research multiple health conditions, including alcohol-related liver disease, Alzheimer’s disease, breast cancer, heart failure, inflammatory bowel disease and Zhu-Tokita-Takenouchi-Kim syndr. ....
Previously, Wende’s group assisted in a study that identified links between DNA methylation in all cause heart failure associated with the ability to use different metabolic fuels to maintain contractility, namely a decrease in oxidative metabolism.[2] An additional study from the group found molecular mechanisms specific to ischemic heart failure, which identified a key epigenetic regulator (i.e. EZH2) as likely having an active role in gene expression regulation involved in both metabolic and structural remodeling.[3] In the new study highlighted here, the research group and lead investigator, former Medical Scientist Training Program (MSTP) student Mark E. Pepin, M.D., Ph.D., followed up on an observation in the prior ischemia study which pointed to the fact that the greatest differences in DNA methylation in their patient population were between race. The group then received funding from the NIH-funded Center for Healthy African American Men through Partnerships (CHAAM ....
Racial diversity and poverty may influence heart-failure morbidity and mortality Race associates with the risk of death from end-stage heart failure. So, identifying the molecular determinants of that risk may help the pursuit of the novel diagnosis and prognosis of heart failure, and its therapy. A University of Alabama at Birmingham study of end-stage heart-failure patients has found that cytosine-p-guanine, or CpG, methylation of the DNA in the heart has a bimodal distribution among the patients, and that race African American versus Caucasian was the sole variable in patient records that explained the difference. A subsequent look at the census tracts where the patients lived showed that the African American subjects lived in neighborhoods with more racial diversity and poverty, suggesting that the underlying variable may be a socioeconomic difference. ....