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Togolese parliament approves Togo's adhesion to the UN convention on the Law of Sea

Last Tuesday, Togolese deputies voted, unanimously, for Togo s adhesion to the United Nations Convention on the Law of the Sea, on the conservation ....

National Development Plan , Doing Busines Enforcing Contracts , Doing Busines Getting , Doing Busines , Property Registration , National Development ,

Guerre contre Russie : L'UE exclut toute adhésion rapide de l'Ukraine

Guerre contre Russie : L'UE exclut toute adhésion rapide de l'Ukraine ....

"Overcoming microenvironment-mediated chemoprotection through stromal g" by Somayeh S. Tarighat, Fei Fei et al.

Environmentally-mediated drug resistance in B-cell precursor acute lymphoblastic leukemia (BCP-ALL) significantly contributes to relapse. Stromal cells in the bone marrow environment protect leukemia cells by secretion of chemokines as cues for BCP-ALL migration towards, and adhesion to, stroma. Stromal cells and BCP-ALL cells communicate through stromal galectin-3. Here, we investigated the significance of stromal galectin-3 to BCP-ALL cells. We used CRISPR/Cas9 genome editing to ablate galectin-3 in stromal cells and found that galectin-3 is dispensable for steady-state BCP-ALL proliferation and viability. However, efficient leukemia migration and adhesion to stromal cells are significantly dependent on stromal galectin-3. Importantly, the loss of stromal galectin-3 production sensitized BCP-ALL cells to conventional chemotherapy. We therefore tested novel carbohydrate-based small molecule compounds (Cpd14 and Cpd17) with high specificity for galectin-3. Consistent with results obtai ....

B Cell Precursor All , Arbohydrate Based Galectin 3 Inhibitor , Drug Resistance , Alectin 3 ,

BBCNEWS BBC News November 2, 2021 21:48:00

Before passing the signal. this evidence also suggests the most likely cause of this was wheel slide and almost certainly the result of low adhesion between the train wheels and the track. we are continuing to pursue this line of investigation amongst a number of others. the driver of the south western train is still in hospital. his injuries are not thought to be as serious as first feared. but today s findings also suggest he did try to stop the train. the weather had been poor and with it being autumn there were leaves on the line making it slippery. although brazil is backing the deforestation deal, tree clearance has soared to a 12 year high under president bolsonaro. it means the amazon rainforest one of the world s greatest defences againstclimate change ? is under growing attack. from hon don iya state in the brazilian amazon our international correspondent, ....

Train Wheels , Wheel Slide , Jair Bolsonaro , Amazon Rainforest , Deforestation Deal , Tree Clearance , Brazilian Amazon , Hon Don Iya ,