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A drug target for erectile dysfunction to help improve fertility, sexual activity, and wellbeing: mendelian randomisation study

Objective To investigate the association of genetically proxied (using a surrogate biomarker) inhibition of phosphodiesterase 5 (PDE5), an established drug target for erectile dysfunction, with fertility, sexual behaviour, and subjective wellbeing.

Design Two sample cis-mendelian randomisation study.

Setting Summary data on genetic associations obtained from the International Consortium for Blood Pressure and UK Biobank.

Participants Individuals of European ancestry from the International Consortium for Blood Pressure (n=757 601) for estimating PDE5 inhibition (using the surrogate biomarker of diastolic blood pressure reduction), and UK Biobank (n=211 840) for estimating the fertility, sexual behaviour, and subjective wellbeing outcomes in male participants.

Intervention Genetically proxied PDE5 inhibition.

Main outcome measures Number of children fathered, number of sexual partners, probability of never having had sexual intercourse, and subjecti ....

United Kingdom , City Of , Dipender Gill , Benjamin Woolf , James Yarmolinsky , Skanda Rajasundaram , Stephen Burgess , Care Research Cambridge Biomedical Centre , Centre Research Ethics Committee , National Institute For Health , Research Council South West Doctoral Training Partnership , Research Council , Regional Development Agency , Novo Nordisk Foundation , Computing Research Centre , British Heart Foundation , Department Of Health , Cancer Research United Kingdom , International Consortium For Blood Pressure , Innovation Medical Research Council , Doctoral Training Partnership , United Kingdom Research , Research Council Integrated Epidemiology Unit Open , University Of Bristol , International Consortium , Blood Pressure ,

Sperm swimming is caused by the same patterns that are believed to dictate zebra stripes

Sperm swimming is caused by the same patterns that are believed to dictate zebra stripes
phys.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from phys.org Daily Mail and Mail on Sunday newspapers.

James Cass , Alan Turing , University Of Bristol , Softlab At Bristol Robotics Laboratory , University Of Bristol Polymaths Lab , School Of Engineering Mathematics , Nature Communications , Computing Research Centre , Hermes Gad , Bristol Polymaths Lab , Engineering Mathematics , Bristol Robotics Laboratory , Advanced Computing Research Centre ,

Zebra Stripes Patterns Linked to Sperm Swimming

Zebra Stripes Patterns Linked to Sperm Swimming
miragenews.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from miragenews.com Daily Mail and Mail on Sunday newspapers.

Hermes Bloomfield , James Cass , Alan Turing , University Of Bristol , Computing Research Centre , School Of Engineering Mathematics , Nature Communications , Softlab At Bristol Robotics Laboratory , Polymaths Lab , Sciences Research Council , Engineering Mathematics , Bristol Robotics Laboratory , Physical Sciences Research Council , Advanced Computing Research Centre ,