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A drug target for erectile dysfunction to help improve fertility, sexual activity, and wellbeing: mendelian randomisation study

Objective To investigate the association of genetically proxied (using a surrogate biomarker) inhibition of phosphodiesterase 5 (PDE5), an established drug target for erectile dysfunction, with fertility, sexual behaviour, and subjective wellbeing.

Design Two sample cis-mendelian randomisation study.

Setting Summary data on genetic associations obtained from the International Consortium for Blood Pressure and UK Biobank.

Participants Individuals of European ancestry from the International Consortium for Blood Pressure (n=757 601) for estimating PDE5 inhibition (using the surrogate biomarker of diastolic blood pressure reduction), and UK Biobank (n=211 840) for estimating the fertility, sexual behaviour, and subjective wellbeing outcomes in male participants.

Intervention Genetically proxied PDE5 inhibition.

Main outcome measures Number of children fathered, number of sexual partners, probability of never having had sexual intercourse, and subjective wellbeing.

Results Genetically proxied PDE5 inhibition was associated with male participants having 0.28 (95% confidence interval 0.16 to 0.39) more children (false discovery rate corrected P<0.001). This association was not identified in female participants. No evidence was found of an association between genetically proxied PDE5 inhibition and number of sexual partners, probability of never having had sexual intercourse, or self-reported wellbeing in male participants.

Conclusions The findings of this study provide genetic support for PDE5 inhibition potentially increasing the number of children fathered by male individuals. Absence of this association in female participants supports increased propensity for sustained and robust penile erections as a potential underlying mechanism. Further studies are required to confirm this, however, and these findings should not promote indiscriminate use of PDE5 inhibitors, which can also have harmful adverse effects.

The data used in this study is publicly available from the Medical Research Council Integrated Epidemiology Unit OpenGWAS platform. The R code used in this study, and genome-wide association studies created for this project, are available from <https://doi.org/10.17605/OSF.IO/MUERZ>. This work was carried out using the computational facilities of the Advanced Computing Research Centre, University of Bristol (<https://www.bris.ac.uk/acrc/>). All genome-wide association studies summary data used in this research, including that created for the applied examples, will be made publicly available.

United-kingdom , Bristol , City-of , Cambridge , Cambridgeshire , British , Dipender-gill , Benjamin-woolf , James-yarmolinsky , Skanda-rajasundaram , Stephen-burgess , Care-research-cambridge-biomedical-centre

Sperm swimming is caused by the same patterns that are believed to dictate zebra stripes

Sperm swimming is caused by the same patterns that are believed to dictate zebra stripes
phys.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from phys.org Daily Mail and Mail on Sunday newspapers.

James-cass , Alan-turing , University-of-bristol , Softlab-at-bristol-robotics-laboratory , University-of-bristol-polymaths-lab , School-of-engineering-mathematics , Nature-communications , Computing-research-centre , Hermes-gad , Bristol-polymaths-lab , Engineering-mathematics , Bristol-robotics-laboratory

Zebra Stripes Patterns Linked to Sperm Swimming

Zebra Stripes Patterns Linked to Sperm Swimming
miragenews.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from miragenews.com Daily Mail and Mail on Sunday newspapers.

Hermes-bloomfield , James-cass , Alan-turing , University-of-bristol , Computing-research-centre , School-of-engineering-mathematics , Nature-communications , Softlab-at-bristol-robotics-laboratory , Polymaths-lab , Sciences-research-council , Engineering-mathematics , Bristol-robotics-laboratory

Sperm Swimming Linked to Alan Turing's Pattern Formation Theory

Sperm Swimming Linked to Alan Turing's Pattern Formation Theory
todayheadline.co - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from todayheadline.co Daily Mail and Mail on Sunday newspapers.

Hermes-bloomfield , Alan-turing , James-cass , Nature-communications , Softlab-at-bristol-robotics-laboratory , Polymaths-lab , University-of-bristol , Computing-research-centre , Sciences-research-council , School-of-engineering-mathematics , Reaction-diffusion-patterns , Hermes-gad

New giant planet evidence of possible planetary collisions

Bristol UK (SPX) Sep 04, 2023 -
A Neptune-sized planet denser than steel has been discovered by an international team of astronomers, who believe its composition could be the result of a giant planetary clash.

TOI-1853b's ma

China , Phil-carter , Luca-naponiello , Jingyao-dou , Zoe-leinhardt , China-scholarship-council , Computing-research-centre , University-of-rome-tor-vergata , Technology-facilities-council , Senior-research , Bristol-school-of-physics , University-of-bristol

New Giant Planet Evidence Of Possible Planetary Collisions

New Giant Planet Evidence Of Possible Planetary Collisions
eurasiareview.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from eurasiareview.com Daily Mail and Mail on Sunday newspapers.

China , Jingyao-dou , Luca-naponiello , Phil-carter , University-of-bristol , Technology-facilities-council , Computing-research-centre , Senior-research , University-of-rome-tor-vergata , China-scholarship-council , School-of-physics , Rome-tor-vergata

New giant planet evidence of possible planetary collisions

New giant planet evidence of possible planetary collisions
sciencedaily.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from sciencedaily.com Daily Mail and Mail on Sunday newspapers.

China , Jingyao-dou , Phil-carter , Luca-naponiello , University-of-rome-tor-vergata , China-scholarship-council , Computing-research-centre , Senior-research , University-of-bristol , Technology-facilities-council , Bristol-school-of-physics , Rome-tor-vergata

University of Bristol Discovers Giant Planet Collision Evidence

University of Bristol Discovers Giant Planet Collision Evidence
miragenews.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from miragenews.com Daily Mail and Mail on Sunday newspapers.

China , Phil-carter , Luca-naponiello , Philip-carter , Zoe-leinhardt , Jingyao-dou , University-of-rome-tor-vergata , Technology-facilities-council , University-of-bristol , University-of-bristol-school-physics , Computing-research-centre , Senior-research

Dell Technologies Interview: At the Univ. of Bristol's Advanced Computing Research Centre 'Typical Doesn't Exist' - High-Performance Computing News Analysis

In this interview, part of our series done on behalf of Dell Technologies, we spoke with Simon Atack, HPC team leader of the Advanced Computing Research [...]

Bristol , City-of , United-kingdom , Computing-research-centre , United-kingdom-university-of-bristol , Dell-technologies , Simon-atack , Advanced-computing-research-centre , Dell-poweredge ,

University of Bristol: Scientists discover when beetles became prolific

Using a previously published and carefully curated 68-gene dataset, the scientists ran a battery of mathematical models to reconstruct the evolution of protein sequences - the results of which, have been published today in Royal Society Open Science.

Czech-republic , Nanjing , Jiangsu , China , Erik-tihelka , Robin-kundrata , Chenyang-cai , Institute-of-geology , Bristol-school-of-earth-sciences , University-of-bristol-advanced-computing-research-centre , Royal-society-open-science , Royal-society-open