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Study highlights the epigenetics of life at high altitudes


Study highlights the epigenetics of life at high altitudes
Humans inhabit an incredible range of environments across the globe, from arid deserts to frozen tundra, tropical rainforests, and some of the highest peaks on Earth. Indigenous populations that have lived in these extreme environments for thousands of years have adapted to confront the unique challenges that they present.
Approximately 2% of people worldwide live permanently at high altitudes of over 2,500 meters (1.5 miles), where oxygen is sparse, UV radiation is high, and temperatures are low. Native Andeans, Tibetans, Mongolians, and Ethiopians exhibit adaptations that improve their ability to survive such conditions. Andeans, for example, display increased chest circumference, elevated oxygen saturation, and a low hypoxic ventilatory response, enabling them to thrive at exceptionally high elevations. ....

Cerro De Pasco , United States , Ainash Childebayeva , Emily Henderson , Cayetano Heredia University , Department Of Archaeogenetics , University Of Michigan , Genome Biology , Wide Epigenetic Signatures , Adaptive Developmental Plasticity , Peruvian Quechua , Andean Altiplano , Cerro De Pasco High Altitude , Max Planck Institute , Human History , Central Asia , Dna Methylation , சிஇஆர்ஆர்ஓ டி பாஸ்கோ , ஒன்றுபட்டது மாநிலங்களில் , எமிலி ஹென்டர்சன் , கேயேதானோ பரம்பரை பல்கலைக்கழகம் , பல்கலைக்கழகம் ஆஃப் மிச்சிகன் , மரபணு உயிரியல் , பரந்த எபிஜெனெடிக் கையொப்பங்கள் , பெருவியன் க்வ்ய்க்ஃப்வா , சிஇஆர்ஆர்ஓ டி பாஸ்கோ உயர் உயரம் ,

High-altitude living has changed more than just the genes of some Peruvians


High-altitude living has changed more than just the genes of some Peruvians
Dec. 22, 2020 , 4:00 PM
Human evolution is at work in the Andes mountains. The Quechua, an Indigenous people in Peru who have lived at altitudes above 2500 meters for at least the past 11,000 years, have evolved genetic adaptations to survive their harsh environment. A new study finds these extreme conditions can change chemical modifications that control the activity of that DNA. These “epigenetic” alterations are the first evidence that growing up in the mountains can alter not just genes, but how the body uses them.
Scientists have long wondered whether environmental stress, like low oxygen concentrations, can shape gene activity in highland people, says anthropologist Cynthia Beall of Case Western Reserve University who studies high altitude adaptations in Tibet. This “pioneering” research shows it is not only possible, says Beall, who was not involved with the study, but likely tha ....

United States , Galen Rowell Getty , Ainash Childebayeva , Cynthia Beall , Freda Kreier , Case Western Reserve University , Genome Biology , Max Planck Institute , ஒன்றுபட்டது மாநிலங்களில் , கேலன் ரோவெல் கெட்டி , சிந்தியா பீல் , வழக்கு மேற்கு இருப்பு பல்கலைக்கழகம் , மரபணு உயிரியல் ,