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Reductive carboxylation of glutamine as a potential target in acute myeloid leukemia

Reductive carboxylation of glutamine as a potential target in acute myeloid leukemia
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Lawrenced Goodridge , Paula Spagnuolo , University Of Guelph , Alessia Roma ,

Avocado discovery may point to leukemia treatment


Avocado discovery may point to leukemia treatment
A compound in avocados may ultimately offer a route to better leukemia treatment, says a new University of Guelph study.
The compound targets an enzyme that scientists have identified for the first time as being critical to cancer cell growth, said Dr. Paul Spagnuolo, Department of Food Science.
Published recently in the journal Blood, the study focused on acute myeloid leukemia (AML), which is the most devastating form of leukemia. Most cases occur in people over age 65, and fewer than 10 per cent of patients survive five years after diagnosis.
Leukemia cells have higher amounts of an enzyme called VLCAD involved in their metabolism, said Spagnuolo. ....

United States , Paul Spagnuolo , Preethi Jayanth , Nawaz Ahmed , Matthew Tcheng , Mcmaster University , Cancer Research Society , Paul Spagnuolo University Of Guelph , University Of Guelph , University Of Waterloo , University Of Colorado , University Of Pittsburgh , Department Of Food Science , Ontario Institute For Cancer Research , Leukemia Research Foundation , Ontario Institute , Alessia Roma , Western University , Princess Margaret Hospital , ஒன்றுபட்டது மாநிலங்களில் , மக்மாஸ்டர் பல்கலைக்கழகம் , புற்றுநோய் ஆராய்ச்சி சமூகம் , பல்கலைக்கழகம் ஆஃப் க்ல்ஃப் , பல்கலைக்கழகம் ஆஃப் வாட்டர்லூ , பல்கலைக்கழகம் ஆஃப் கொலராடோ , பல்கலைக்கழகம் ஆஃப் பிட்ஸ்பர்க் ,

Avocado discovery may point to leukemia treatment


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IMAGE: A compound in avocados may ultimately offer a route to better leukemia treatment, says a new University of Guelph study.
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Credit: University of Guelph
A compound in avocados may ultimately offer a route to better leukemia treatment, says a new University of Guelph study.
The compound targets an enzyme that scientists have identified for the first time as being critical to cancer cell growth, said Dr. Paul Spagnuolo, Department of Food Science.
Published recently in the journal
Blood, the study focused on acute myeloid leukemia (AML), which is the most devastating form of leukemia. Most cases occur in people over age 65, and fewer than 10 per cent of patients survive five years after diagnosis. ....

United States , Paul Spagnuolo , Preethi Jayanth , Nawaz Ahmed , Matthew Tcheng , Mcmaster University , Cancer Research Society , University Of Guelph , University Of Waterloo , University Of Colorado , University Of Pittsburgh , Department Of Food Science , Ontario Institute For Cancer Research , Leukemia Research Foundation , Ontario Institute , Alessia Roma , Western University , Princess Margaret Hospital , ஒன்றுபட்டது மாநிலங்களில் , மக்மாஸ்டர் பல்கலைக்கழகம் , புற்றுநோய் ஆராய்ச்சி சமூகம் , பல்கலைக்கழகம் ஆஃப் க்ல்ஃப் , பல்கலைக்கழகம் ஆஃப் வாட்டர்லூ , பல்கலைக்கழகம் ஆஃப் கொலராடோ , பல்கலைக்கழகம் ஆஃப் பிட்ஸ்பர்க் , துறை ஆஃப் உணவு அறிவியல் ,