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Indian-origin businessman shot dead in Columbus, GA

Indian-origin businessman shot dead in Columbus, GA
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How to Protect Neurons and Encourage Their Growth

How to Protect Neurons and Encourage Their Growth
Many neurodegenerative conditions, from glaucoma to Alzheimer’s disease, are characterized by injury to axons the long, slender projections that conduct electrical impulses from one nerve cell to another, facilitating cellular communications. Injury to axons often leads to neuronal impairment and cell death.
Researchers know that inhibiting an enzyme called dual leucine zipper kinase (DLK) appears to robustly protect neurons in a wide range of neurodegenerative diseases models, but DLK also inhibits axonal regeneration. Until now, there have been no effective methods to modify genes to improve both the long-term survival of neurons and promote regeneration. ....

United States , San Diego , University Of Miami , University Of California San Diego , Johnl Bixby , Vancep Lemmon , Karlj Wahlin , Mikaelaj Louie , Donaldj Zack , Derek Welsbie , Tianlun Lu , Vinod Jaskula , Xin Duan , Cassidyd Lee , Robertn Weinreb , Amitk Patel , Hassan Al Ali , Katherinel Mitchell , Mait Vu , Risam Broyer , Johns Hopkins University , Us Centers For Disease , National Institutes Of Health , E Matilda Ziegler Foundation , Glaucoma Research Foundation Catalyst For The Cure , Sight Foundation ,

Researchers discover clue to how to protect neurons and encourage their growth

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IMAGE: Example of retinal ganglion cells with axons and dendrites in the retina of a healthy eye.
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Credit: UC San Diego Health Sciences
Many neurodegenerative conditions, from glaucoma to Alzheimer s disease, are characterized by injury to axons the long, slender projections that conduct electrical impulses from one nerve cell to another, facilitating cellular communications. Injury to axons often leads to neuronal impairment and cell death.
Researchers know that inhibiting an enzyme called dual leucine zipper kinase (DLK) appears to robustly protect neurons in a wide range of neurodegenerative diseases models, but DLK also inhibits axonal regeneration. Until now, there have been no effective methods to modify genes to improve both the long-term survival of neurons and promote regeneration. ....

United States , San Diego , University Of Miami , University Of California San Diego , Johnl Bixby , Vancep Lemmon , Karlj Wahlin , Mikaelaj Louie , Donaldj Zack , Derek Welsbie , Tianlun Lu , Vinod Jaskula , Xin Duan , Cassidyd Lee , Robertn Weinreb , Amitk Patel , Hassan Al Ali , Katherinel Mitchell , Mait Vu , Risam Broyer , Johns Hopkins University , Us Centers For Disease , Uc San Diego Health , Shiley Eye Institute , California San Diego School , Diego Health ,