"Causal effect of gut-microbiota-derived metabolite trimethylamine N-ox" by Hang Zhou, Yuqi Luo et al.
Background and purpose: It has been suggested that trimethylamine N-oxide (TMAO) is related to Parkinson's disease (PD) in observational studies. However, the direction of this association is inconsistent. An exploratory Mendelian randomization study was conducted to investigate whether TMAO and its precursors have a causal relationship with PD. Methods: Summary statistics were obtained for single nucleotide polymorphisms related to circulating levels of TMAO, betaine, carnitine and choline, and the corresponding data for the risk, age at onset and progression of PD from genome-wide assoc...
Source: uow.edu.au