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Northwestern Medicine scientists have discovered the Achilles heel of chemotherapy-resistant ovarian cancer—its hunger for cholesterol.

Northwestern Medicine researchers have uncovered the Achilles heel of chemotherapy-resistant ovarian cancer – its need for cholesterol — and how to utilize it to get rid of it.

Women diagnosed with ovarian cancer may initially respond well to chemotherapy, but the majority of them will develop resistance to treatment and die from the disease.

Drug is being developed for clinical trials Drug selectively attacks cancer cells, leaves normal cells unharmed CHICAGO --- Scientists at Northwestern Medicine have developed a novel therapy to trick cancer cells into gobbling up what they think is their favorite food - cholesterol - which actually triggers their destruction. What appears to them as a cholesterol-loaded particle is actually a synthetic nanoparticle that binds to the cancer cells and starves them to death. Although the research looked at lymphoma cells, scientists say the new experimental drug from Northwestern could be ef...