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Alzheimer’s disease may be inherited more often than previously known, according to a new study that paints a clearer picture of a gene long known to be linked to the common form of dementia.
A recent study conducted by researchers in Nature Medicine has highlighted the potential risks of a genetic variant of the Alzheimer's risk gene APOE4. Titled "APOE4 Homozygosity Represents a Unique Genetic Form of Alzheimer's Disease," the study reveals that individuals carrying two copies of the Alzheimer's risk gene APOE4 are more likely to exhibit biological indicators of Alzheimer's pathology in the brain, as well as biomarkers of the disease in cerebrospinal fluid and PET scans.
The team behind the drug developed it after pinpointing one of the main causes of Alzheimer's, a protein called ApoE4 in the Alzheimer's gene.
The FDA's decision will allow the drug known as Leqembi to be widely available and covered through Medicare.