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First Structure of CNG Channel in Rod Cells Obtained

Cryo-electron microscopy of CNG channel proteins in rod cells shed light on the mechanisms behind seeing in dim light. ....

Switzerland General , Diane Barret , Benjamin Kaupp , Gebhard Schertler , Jacopo Marino Paul Scherrer , Jacopo Marino , Paul Scherrer ,

More insight into how vision works

PSI scientists have shed light on an important component of the eye: a protein in the rod cells of the retina which helps us see in dim light. Acting ....

Diane Barret , Jacopo Marino , Benjamin Kaupp , Gebhard Schertler , Paul Scherrer Institute Brigitte Osterath , Laboratory Of Biomolecular Research , Paul Scherrer Institute Markus Fischer , Nature Structural , Paul Scherrer , Markus Fischer ,

Researchers investigate structural changes in snap-frozen proteins


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IMAGE: when cAMP (orange) binds. This also changes the distance between the two molecular magnets attached to the channel (black).
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Credit: (c) Tobias Hett / Universität Bonn und Forschungszentrum caesar
Researchers at the University of Bonn and the research center caesar have succeeded in ultra-fast freezing proteins after a precisely defined period of time. They were able to follow structural changes on the microsecond time scale and with sub-nanometer precision. Owing to its high spatial and temporal resolution, the method allows tracking rapid structural changes in enzymes and nucleic acids. The results are published in the
Journal of the American Chemical Society. ....

United States , Nordrhein Westfalen , Ulrich Benjamin Kaupp , Benjamin Kaupp , Olav Schiemann , Theoretische Chemie , Helmut Grubm , Tobias Hett , University Of Osnabr , Reinhart Koselleck Program , German Research Foundation , University Of Bonn , Journal Of The American Chemical Society , Delft University , Transdisciplinary Research Area Building Blocks Of Matter , Max Planck Society , Max Planck Institute For Biophysical Chemistry , American Chemical , Theoretical Chemistry , Max Planck Institute , Biophysical Chemistry , Transdisciplinary Research Area , Spatio Temporal Resolution , Conformational Changes , Microsecond Freeze Hyperquenching , American Chemical Society ,