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Scientists determined the atomic structure of a coronavirus protein

Scientists determined the atomic structure of a coronavirus protein
The odd structure of ORF8.
Co-authors Cosmo Buffalo (left) and Richard Hooy discussing the ORF8 structure, shown as a ribbon diagram and space-filling model. (Credit: Kevin Larsen)
The molecular basis for the severity and rapid spread of the COVID-19 disease caused by SARS-CoV-2 is mostly unknown.
To do so, a team of HIV researchers, cellular biologists, and biophysicists collaborated to determine the atomic structure of a coronavirus protein. The protein is thought to the pathogen to evade and dampen response from human immune cells.
The accessory protein ORF8 is one of the most rapidly evolving betacoronavirus proteins that have been proposed to interfere with immune responses. ....

United States , Marc Allaire , James Hurley , Lawrence Berkeley National Laboratory Lab , Berkeley Lab Advanced Light Source , Berkeley Center , Lawrence Berkeley National Laboratory , Berkeley Lab , Structural Biology , Advanced Light Source , ஒன்றுபட்டது மாநிலங்களில் , மார்க் அல்லேர் , ஜேம்ஸ் ஹர்லி , லாரன்ஸ் பெர்க்லி தேசிய ஆய்வகம் ஆய்வகம் , பெர்க்லி மையம் , லாரன்ஸ் பெர்க்லி தேசிய ஆய்வகம் , பெர்க்லி ஆய்வகம் , கட்டமைப்பு உயிரியல் ,

Researchers determine the atomic structure of protein that helps coronavirus to evade immune cells

Researchers determine the atomic structure of protein that helps coronavirus to evade immune cells
A team of HIV researchers, cellular biologists, and biophysicists who banded together to support COVID-19 science determined the atomic structure of a coronavirus protein thought to help the pathogen evade and dampen response from human immune cells.
The structural map - which is now published in the journal
PNAS, but has been open-access for the scientific community since August - has laid the groundwork for new antiviral treatments tailored specifically to SARS-CoV-2, and enabled further investigations into how the newly emerged virus ravages the human body. ....

United States , Marc Allaire , James Hurley , Emily Henderson , Lawrence Berkeley National Laboratory Lab , Berkeley Lab Advanced Light Source , Berkeley Center , Bioimaging Division , Berkeley Lab Molecular Biophysics , Lead Author , Former Faculty Scientist , Lawrence Berkeley National Laboratory , Berkeley Lab , Structural Biology , Advanced Light Source , Molecular Biophysics , Integrated Bioimaging , Corona Virus , Amino Acid , Sars Cov 2 , X Ray , ஒன்றுபட்டது மாநிலங்களில் , மார்க் அல்லேர் , ஜேம்ஸ் ஹர்லி , எமிலி ஹென்டர்சன் , லாரன்ஸ் பெர்க்லி தேசிய ஆய்வகம் ஆய்வகம் ,

The Odd Structure of ORF8: Mapping the Coronavirus Protein Linked to Disease Severity

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IMAGE: Marc Allaire, pictured in June 2020, setting up one of the Advanced Light Source s X-ray crystallography beamlines.
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Credit: Marilyn Sargent/Berkeley Lab
A team of HIV researchers, cellular biologists, and biophysicists who banded together to support COVID-19 science determined the atomic structure of a coronavirus protein thought to help the pathogen evade and dampen response from human immune cells. The structural map - which is now published in the journal
PNAS, but has been open-access for the scientific community since August - has laid the groundwork for new antiviral treatments tailored specifically to SARS-CoV-2, and enabled further investigations into how the newly emerged virus ravages the human body. ....

United States , Marc Allaire , James Hurley , University Of California , Berkeley Lab Advanced Light Source , Berkeley Center , Lawrence Berkeley National Laboratory , Bioimaging Division , Lawrence Berkeley National Laboratory Lab , Office Of Science , Berkeley Lab , Berkeley Lab Molecular Biophysics , Structural Biology , Advanced Light Source , Molecular Biophysics , Integrated Bioimaging , Biomechanics Biophysics , Molecular Biology , Medicine Health , ஒன்றுபட்டது மாநிலங்களில் , மார்க் அல்லேர் , ஜேம்ஸ் ஹர்லி , பல்கலைக்கழகம் ஆஃப் கலிஃபோர்னியா , பெர்க்லி மையம் , லாரன்ஸ் பெர்க்லி தேசிய ஆய்வகம் , லாரன்ஸ் பெர்க்லி தேசிய ஆய்வகம் ஆய்வகம் ,

Unique X-Ray Microscope Reveals Dazzling 3D Cell Images

Unique X-Ray Microscope Reveals Dazzling 3D Cell Images
The planet is comprised of continents and islands, each with unique cultures and resources. One area may be well known for growing food, another for manufacturing building materials, and yet despite their differences and distance from one another, the regions are linked by global processes. Living cells are built on a similar concept. For example, one part of the cell produces fuel that powers life, and another part makes the simple building blocks that are then assembled into complex structures inside the cell. To fully understand cells, we need to characterize the structures that make them up, and to identify their contents. ....

United States , Carolyn Larabell , Valentina Loconte , National Center , Berkeley Lab Advanced Light Source , National Institutes Of Health , Cell Consortium , Bioimaging Division , Office Of Science , Berkeley Lab , Department Of Energy Office Science , Advanced Light Source , Science Advances , X Ray Tomography , Molecular Biophysics , Integrated Bioimaging , Energy Office , National Institutes , ஒன்றுபட்டது மாநிலங்களில் , தேசிய மையம் , தேசிய நிறுவனங்கள் ஆஃப் ஆரோக்கியம் , செல் கூட்டமைப்பு , அலுவலகம் ஆஃப் அறிவியல் , பெர்க்லி ஆய்வகம் , துறை ஆஃப் ஆற்றல் அலுவலகம் அறிவியல் , எக்ஸ் ராய் டோமோகிராபி ,

Berkeley Lab's Top 10 Science Stories of 2020

Berkeley Lab’s Top 10 Science Stories of 2020
It was a year dominated by COVID-19 research, along with some beetles, batteries, and a Nobel Prize
December 22, 2020
T
he coronavirus pandemic has taught us many valuable lessons this year, and perhaps foremost among them is the importance of science.
Researchers at the Department of Energy’s Lawrence Berkeley National Laboratory (Berkeley Lab) have always strived to find science-based solutions for society’s most pressing issues. This year our scientists, while continuing to focus on the immense challenges of energy, climate change, and understanding the mysteries of the universe, also stepped up to face an unprecedented health crisis, using their expertise in everything from nanoscience to machine learning to contribute new knowledge to COVID-19. ....

San Francisco Bay , United States , Heinz Frei , Jeff Dror , Tom Kirchstetter , Andrew Ells , Brittany Hosea , Georgios Katsoukis , Jun Jo , Brett Helms , Emmanuelle Charpentier , Peter Hosemann , Irfan Siddiqi , Chengyin Fu , Jennifer Doudna , University Of California , Berkeley Lab Indoor Environment Group , National Quantum Information Science , Laboratory Directed Research , Berkeley Lab Theory Group , Research Centers , Office Of Science , Kellyj Owen Berkeley Lab , Thor Swift Berkeley Lab , Marilyn Sargent Berkeley Lab , Department Of Energy ,