Trastuzumab deruxtecan superior to physician's choice treatment in patients with metastatic HER2-positive breast cancer
1. Progression-free survival was greater in the trastuzumab group compared to standard care (17.8 months vs. 6.9 months). 2. Drug-related interstitial lung disease was more common with patients receiving trastuzumab deruxtecan. Evidence Rating Level: 1 (Excellent) Study Rundown: A large proportion of breast cancers are characterized by overexpression of HER2 receptors. While first-line therapy for