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ADC Choices Require Discretion in HER2-Negative MBC

With multiple antibody drug conjugate options now available for patients with HER2-negative metastatic breast cancer, clinicians must consider a variety of factors when selecting and sequencing therapies. ....

Memorial Sloan Kettering Cancer Center , New York , United States , Trastuzumab Deruxtecan , Joshuaz Drago , Sacituzumab Govitecan , Chemotherapy Foundation Symposium Innovative Cancer Therapy For , Metastatic Triple Negative Breast , Previously Treated , Low Advanced Breast ,

Trastuzumab deruxtecan superior to physician's choice treatment in patients with metastatic HER2-positive breast cancer

1. Progression-free survival was greater in the trastuzumab group compared to standard care (17.8 months vs. 6.9 months). 2. Drug-related interstitial lung disease was more common with patients receiving trastuzumab deruxtecan. Evidence Rating Level: 1 (Excellent) Study Rundown: A large proportion of breast cancers are characterized by overexpression of HER2 receptors. While first-line therapy for ....

United States , Trastuzumab Deruxtecan , Rating Level , Previously Treated , Low Advanced Breast , Between Sept , North America , Advanced Breast Cancer , Breast Cancer , Her2 Positive Breast Cancer , Interstitial Lung Disease , Metastatic Breast Cancer , Trastuzumab Emtansine , Chronic Disease ,