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Oak Brook, IL - The April edition of SLAS Discovery is a special issue on advances in protein degradation curated by guest editors M. Paola Castaldi, Ph.D., and Stewart L. Fisher, Ph.D. Targeted protein degradation has generated interest within the drug discovery arena due to the inhibition of one particular function of a protein not often delivering the successful results that comes from whole-protein depletion. The pharmacology of PROTACs present challenges, however, namely for the development of orally bioavailable drugs. In the article "Target Validation Using PROTACs: Applying the Four ...

 E-Mail IMAGE: Students at St. Georges Technical High School in Middletown, Delaware are the first high school students in the United States to use the innovative CRISPR in a Box educational gene... view more  Credit: ChristianaCare St. Georges Technical High School in southern New Castle County, Delaware is the first high school in the United States to use ChristianaCare Gene Editing Institute's innovative CRISPR in a Box Educational Toolkit™ in a science class. CRISPR in a Box brings to life the much-heralded CRISPR gene editing technology - the "genetic scissors" that allow scien...

Bipolar disorder affects millions of Americans, causing dramatic swings in mood and, in some people, additional effects such as memory problems.

 E-Mail IMAGE: Researchers from The University of Tokyo develop a novel device for the safe and effective transplantation of human induced pluripotent stem cell (iPSC)-derived pancreatic beta-cells in type I diabetes mellitus... view more  Credit: Institute of Industrial Science, the University of Tokyo Tokyo, Japan - Type I Diabetes Mellitus (T1D) is an autoimmune disorder leading to permanent loss of insulin-producing beta-cells in the pancreas. In a new study, researchers from The University of Tokyo developed a novel device for the long-term transplantation of iPSC-derived human...

 E-Mail IMAGE: A mouse brain section highlighting the hippocampus is overlaid with the molecular structures of the anesthetics isoflurane (purple), medetomidine/midazolam/fentanyl (orange), and ketamine/xylazine (red). The four panels in the lower part... view more  Credit: Simon Wiegert, CC-BY Memory loss is common after general anesthesia, particularly for events occurring immediately before surgery--a phenomenon called retrograde amnesia. But a new study publishing on April 1st 2021 in the open access journal PLOS Biology, led by Simon Wiegert at the University Medical Center Ha...