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"Fabricating delivery platforms for wound management and tissue regener" by Luciana Yumiko Daikuara

Skin provides the protective surface for animals and humans and is therefore prone to physical, chemical, and biological injuries. In all but superficial wounds, the capacity to repair by regeneration is lost and the mechanisms involved in wound closure are unable to restore the skin’s original functions. In this context, skin repair is achieved using surgical techniques including skin grafts, and a range of synthetic or biological scaffolds. Wounds impact millions of patients every year and represent a serious cause of morbidity and mortality worldwide. The increase in need for better skin repair, in part due to issues such as the aging population coupled with chronic conditions has driven the development of products to enhance therapeutic outcomes, yet current treatment outcomes are far from ideal and complete replication of the cellular structure and tissue functional requirements of skin remains a challenge. General aims: Address the major drawbacks of available skin substitutes ....

Skin Regeneration , Kin Printing , Latelet Lysate Bioink ,

"Hydrogel-based 3D hybrid bioprinting towards cartilage application" by Yuchao Fan

Three-dimensional (3D) bioprinting has been applied to fabricate constructs that facilitate cartilage regeneration, as it provides the ability to assemble biomaterials with cells in a spatially controlled manner. For conventional bioprinting, the bioink is applied alone to fabricate constructs. However, this strategy is hitting a bottleneck due to the challenging requirements of bioink formulation. The bioinks applied in conventional bioprinting have to fulfill both the physicochemical requirements for fabrication, as well as the biological requirements associated with the processing of the embedded cells. To address this issue, hybrid bioprinting techniques that simultaneously apply two (or multiple) inks have been explored since 2011. Hybrid bioprinting strategies using thermoplastics and hydrogels have demonstrated benefits for fabricating cartilage constructs with controlled stiffness and complex structure. Nevertheless, the adhesion between the thermoplastics as reinforced structu ....

Tissue Engineering , 3d Bioprinting ,

"Parameter optimisation of coaxial Melt Electrowriting" by Anne-Katrin Gruska

Melt electrowriting (MEW) is an additive manufacturing technique that combines the advantages of both, solution electrospinning and fused filament fabrication by allowing the deposition of ultra-fine fibres in a controlled way without the necessity for dispersion of the material being prepared in toxic solvents. This approach is promising for the research field of tissue engineering that requires not only different types of materials but also different manufacturing techniques for scaffolds that are supposed to provide robust but flexible support, which facilitates cell growth without causing damage to the surrounding tissue. Recent advances in MEW technology (Mar 2018) that allow the processing through coaxial extrusion geometries are examined in the context of composite materials and their possible application as for example drug delivery systems. In this study, poly(ε-caprolactone) (PCL) containing different percentages of different fluorophores was prepared using a precipitation p ....

Melt Electrowriting , Additive Manufacturing ,