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First CRISPR-armed phage therapeutic can specifically target and remove E. coli in the human gut

SNIPR Biome ApS ("SNIPR"), the company pioneering CRISPR-based microbial gene therapy, announces today that Nature Biotechnology has published research findings from its preclinical work on  SNIPR001, the first CRISPR-armed phage therapeutic developed to specifically target and remove E. coli, including antibiotic-resistant strains, in the human gastrointestinal tract. ....

Lily Ramsey , Nature Biotechnology , E Coli , Antimicrobial Resistance , Gastrointestinal Tract , Gene Therapy ,

Reconstructing ancient bacterial genomes can revive previously unknown molecules – offering a potential source for new antibiotics

Ancient microbes likely produced natural products their descendants today do not. Tapping into this lost chemical diversity could offer a potential source of new drugs. ....

Upper Paleolithic , Pleistocene Epoch , Ancient Dna , Na Sequencing , Drug Discovery , Genetic Sequence , Natural Products , Pleistocene Era , Ooth Fossils ,

Insights into potential targets for improving diagnosis and treatment of dilated cardiomyopathy

Announcing a new article publication for Cardiovascular Innovations and Applications journal. Dilated cardiomyopathy (DCM) is a non-ischemic heart disease that poses a substantial global health burden, but its underlying molecular mechanisms remain poorly understood. ....

Emily Henderson , Cardiovascular Innovations ,