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Novel guidelines help select optimal deconvolution method


Date Time
Novel guidelines help select optimal deconvolution method
Biomedical scientists are increasingly using deconvolution methods, those used to computationally analyze the composition of complex mixtures of cells. One of their challenges is to select one method that is appropriate for their experimental conditions among nearly 50 available.
To help with method selection, researchers at Baylor College of Medicine and the Jan and Dan Duncan Neurological Research Institute at Texas Children’s Hospital have extensively evaluated 11 deconvolution methods that are based on RNA-sequencing (RNA-seq) data analysis, determining each method’s individual strengths and weaknesses in a variety of scenarios. From these analyses, the researchers derived guidelines that scientists can use to determine the deconvolution method that optimally fits their needs. The study appears in the journal Genome Biology. ....

United States , Baylor College Of Medicine , Haijing Jin , Zhandong Liu , Chao Family Foundation , Dan Duncan Neurological Research Institute , Huffington Foundation , National Institute , Cancer Prevention Research Institute Of Texas , Baylor College , Texas Children , Bioinformatics Core , Dan Duncan Neurological Research , General Medical Sciences , Cancer Prevention Research Institute , Houston Endowment , ஒன்றுபட்டது மாநிலங்களில் , பேலர் கல்லூரி ஆஃப் மருந்து , குழப்பம் குடும்பம் அடித்தளம் , டான் டங்கன் நரம்பியல் ஆராய்ச்சி நிறுவனம் , ஹஃபிங்டன் அடித்தளம் , தேசிய நிறுவனம் , புற்றுநோய் ப்ரெவெந்ஶந் ஆராய்ச்சி நிறுவனம் ஆஃப் டெக்சாஸ் , பேலர் கல்லூரி , டெக்சாஸ் குழந்தைகள் , உயிர் தகவலியல் கோர் ,

WCM-Q researchers study the role of proteins in obesity


 07 Apr 2021 - 20:19
The Peninsula
Doha: A study of proteins circulating in the bloodstream has identified several proteins that may play a causal role in obesity, making them potential targets for drugs and therapies. 
Researchers at Weill Cornell Medicine – Qatar examined more than 1,000 proteins in samples taken from individuals in Qatar as part of the Qatar Metabolomics Study on Diabetes, alongside data from European studies. In total, more than 4,600 individuals were involved in the three previous studies. The work was conducted in collaboration with the German Research Center for Environmental Health. 
Using genetics to isolate the relevant proteins, they found that six proteins had a causal relationship with body mass index, even when other lifestyle factors were taken into consideration. Three of those proteins were found to contribute towards obesity, and at the same time, reflect the biological mechanisms resulting from increased body mass index. ....

Ad Daw Ah , Shaza Zaghlool , Karsten Suhre , Qatar Foundation , German Research Center , Environmental Health , Biomedical Research Program , Qatar National Research Fund , Weill Cornell Medicine , Qatar Metabolomics Study , Bioinformatics Core , Qatar National Research , கார்ஸ்டன் சுறே , கத்தார் அடித்தளம் , ஜெர்மன் ஆராய்ச்சி மையம் , சுற்றுச்சூழல் ஆரோக்கியம் , உயிர் மருத்துவ ஆராய்ச்சி ப்ரோக்ர்யாம் , கத்தார் தேசிய ஆராய்ச்சி நிதி , வெயில் கார்னெல் மருந்து , உயிர் தகவலியல் கோர் , கத்தார் தேசிய ஆராய்ச்சி ,