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New genetic copycatchers detect efficient and precise CRISPR editing in a living organism

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IMAGE: Red fluorescent detector proteins in fruit flies reveal detection from an actual copying experiment (left) and how perfect copying would appear (right). Fluorescent cells in the left panel also lack.
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Credit: Zhiqian Li
Researchers at the University of California San Diego have laid the groundwork for a potential new type of gene therapy using novel CRISPR-based techniques.
Working in fruit flies and human cells, research led by UC San Diego Postdoctoral Scholar Zhiqian Li in Division of Biological Sciences Professor Ethan Bier s laboratory demonstrates that new DNA repair mechanisms could be designed to address the effects of debilitating diseases and damaged cell conditions. ....

San Diego , United States , University Of California San Diego , Sushil Devkota , Stephen Hedrick , Nimi Marcel , Zhiqian Li , Valentino Gantz , Ankush Auradkar , Nature Communications , Tata Institute For Genetics , National Institutes Of Health , Division Of Biological Sciences Professor Ethan Bier , Synbal Inc , Agragene Inc , California San Diego , Biological Sciences Professor Ethan Bier , Tata Institute , National Institutes , Frontiers Group Distinguished Investigators Award , Tata Trusts , சான் டியாகோ , ஒன்றுபட்டது மாநிலங்களில் , பல்கலைக்கழகம் ஆஃப் கலிஃபோர்னியா சான் டியாகோ , ஸ்டீபன் ஹெட்ரிக் , வாலண்டினோ காண்டஜ ,

Novel 'CopyCatcher' detects when precise copying of genetic information takes place in cells

Novel CopyCatcher detects when precise copying of genetic information takes place in cells
Researchers at the University of California San Diego have laid the groundwork for a potential new type of gene therapy using novel CRISPR-based techniques.
Working in fruit flies and human cells, research led by UC San Diego Postdoctoral Scholar Zhiqian Li in Division of Biological Sciences Professor Ethan Bier s laboratory demonstrates that new DNA repair mechanisms could be designed to address the effects of debilitating diseases and damaged cell conditions.
The scientists developed a novel genetic sensor called a CopyCatcher, which capitalizes on CRISPR-based gene drive technology, to detect instances in which a genetic element is copied precisely from one chromosome to another throughout cells in the body of a fruit fly. ....

San Diego , United States , University Of California San Diego , Zhiqian Li , Emily Henderson , Nature Communications , Tata Institute For Genetics , Division Of Biological Sciences Professor Ethan Bier , California San Diego , Biological Sciences Professor Ethan Bier , Tata Institute , சான் டியாகோ , ஒன்றுபட்டது மாநிலங்களில் , பல்கலைக்கழகம் ஆஃப் கலிஃபோர்னியா சான் டியாகோ , எமிலி ஹென்டர்சன் , இயற்கை தகவல்தொடர்புகள் , டாடா நிறுவனம் க்கு ஜெநெடிக்ஸ் , கலிஃபோர்னியா சான் டியாகோ , டாடா நிறுவனம் ,