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Interaction inhibitor blocks toxic effect of glutamate in ALS

The discovery of a complex formed by two types of ion channels in neurons has allowed researchers from Heidelberg University to develop an inhibitor that stopped motor neuron degeneration in amyotrophic lateral sclerosis (ALS) in mouse models and human brain organoids. ....

Heidelberg University , Bioworld Science , Neurology Psychiatric , Amyotrophic Lateral Sclerosis , Fundamental Pharma Gmbh , Nmda Receptor , Fp 802 , Drug Design , Rug Delivery And Technologies ,

Enzyme degrader could avoid drug resistance in B-cell cancers

Bruton tyrosine kinase (BTK) enzyme inhibitors used to treat B-cell cancers, including chronic lymphocytic leukemia (CLL) and non-Hodgkin lymphoma, also produce resistance by causing mutations in the protein. Now, a study on the BTK degrader NX-2127 showed the compound could be effective in eliminating BTK regardless of its mutations. ....

Bioworld Science , Drug Resistance , Drug Design , Rug Delivery And Technologies , Btk Inhibitors , Non Hodgkin Lymphoma , Memorial Sloan Kettering Cancer Center , Chronic Lymphocytic Leukemia , Nx 2127 , Bruton Tyrosine Kinase , Nurix Pharmaceuticals Inc ,

Brain mimetic co-culture reveals new targets in lung cancer brain metastases

Researchers at Kanazawa University, Japan, have reported a mixed-glial culture on/in soft substrate (MGS) platform to investigate cancer-glia interactions in vitro. Using this model, they showed that astrocytes favored brain metastasis by promoting metabotropic glutamate mGlu1 receptor (mGluR1) expression in cancer cells and stabilizing EGFR. Eishu Hirata, an associate professor at the Cancer Research Institute, Division of Tumor Cell Biology and Bioimaging at Kanazawa University, and his team
published their work on Feb. 2, 2024, in Developmental Cell. ....

Eishu Hirata , Division Of Tumor Cell Biology , Researchers At Kanazawa University , Cancer Research Institute , Kanazawa University , Tumor Cell Biology , Bioworld Science , Non Small Cell Lung Cancer , Brain Metastases , Ly 456236 , Co Culture , Mglu1 Receptor ,

KIBRA restores tau-driven damage in Alzheimer's disease

It is well known that protein tau forms aggregates in the brain in neurodegenerative diseases such as Alzheimer’s disease (AD) that are also known as tauopathies. Accumulation of protein tau in the brain leads to the cell toxicity and promotes the loss of synaptic plasticity, which in turn causes memory loss. As reported on Feb. 1, 2024, in The Journal of Clinical Investigation, assistant professor Tara Tracy and her research team from the Buck Institute for Research on Aging have discovered a protein in the brain that could restore this damage induced by protein tau. ....

Tara Tracy , Buck Institute For Research On , Clinical Investigation , Buck Institute , Bioworld Science , Alzheimers Disease , Synaptic Plasticity , Buck Institute For Research On Aging , Memory Loss , Protein Kibra , Neurology Psychiatric ,

SARS-CoV-2 peptides cause severe illness when virus breaks

COVID-19 severity remains open to several questions. Researchers at the University of California Los Angeles (UCLA) have revealed how SARS-CoV-2 causes acute inflammation instead of the symptoms of a common cold. This effect could be initiated by the peptide fragments of the coronavirus released when the host eliminates the virus, which can form pro-inflammatory complexes that trigger an amplified immune response. ....

University Of California Los Angeles , California Los Angeles , Bioworld Science , Sars Cov 2 , Covid 19 , Antimicrobial Peptides , California Nanosystems Institute , University Of California , Los Angeles ,