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Novadip Biosciences SA announces significant clinical milestones for both of its clinical-stage programs

/PRNewswire/ -- Novadip Biosciences SA ("Novadip" or "the Company"), a clinical-stage biopharmaceutical company developing a new class of regenerative tissue...

Belgium , Baltimore , Maryland , United-states , Brussels , Bruxelles-capitale , Denis-dufrane , Novadip-biosciences , J-pediatr-orthop , Acta-orthop-scand , Judy-ashworth , Pierre-louis-docquier

Cartilage-like protein hydrogels engineered via entanglement

Load-bearing tissues, such as muscle and cartilage, exhibit high elasticity, high toughness and fast recovery, but have different stiffness (with cartilage being significantly stiffer than muscle)1–8. Muscle achieves its toughness through finely controlled forced domain unfolding–refolding in the muscle protein titin, whereas articular cartilage achieves its high stiffness and toughness through an entangled network comprising collagen and proteoglycans. Advancements in protein mechanics and engineering have made it possible to engineer titin-mimetic elastomeric proteins and soft protein biomaterials thereof to mimic the passive elasticity of muscle9–11. However, it is more challenging to engineer highly stiff and tough protein biomaterials to mimic stiff tissues such as cartilage, or develop stiff synthetic matrices for cartilage stem and progenitor cell differentiation12. Here we report the use of chain entanglements to significantly stiffen protein-based hydrogels without compromising their toughness. By introducing chain entanglements13 into the hydrogel network made of folded elastomeric proteins, we are able to engineer highly stiff and tough protein hydrogels, which seamlessly combine mutually incompatible mechanical properties, including high stiffness, high toughness, fast recovery and ultrahigh compressive strength, effectively converting soft protein biomaterials into stiff and tough materials exhibiting mechanical properties close to those of cartilage. Our study provides a general route towards engineering protein-based, stiff and tough biomaterials, which will find applications in biomedical engineering, such as osteochondral defect repair, and material sciences and engineering. The introduction of chain entanglements into protein-based hydrogels yields hydrogels with high stiffness, high toughness, fast recovery and ultrahigh compressive strength, with mechanical properties close to those of cartilage.

International-cartilage-repair-society , Mechanical-design , Rubber-elasticity , Synovial-fluid , Sports-exerc , Soft-matter , Tissue-res , Cartilage-repair-society , Bone-joint ,

Novadip Biosciences SA Announces First Pediatric Patient with Congenital Pseudoarthrosis of the Tibia Undergoes Implantation with NVD-003, an Autologous Tissue Regeneration Product, in Phase 1b/2a US/EU Clinical Trial

Second patient scheduled for implantation with NVD-003 in June 2023 Pivotal trial is expected to begin in the second half of 2024* Novadip Biosciences SA ("Novadip" or "the Company"), a clinical-stage

Brussels , Bruxelles-capitale , Belgium , J-pediatr-orthop , Pierre-louis-docquier , Denis-dufrane , Novadip-biosciences , Acta-orthop-scand , Gewinn-nur , Novadip-bioscience , Jim-heins , Judy-ashworth

New data underscores material benefits of Smith+Nephew's OXINIUM™ DH Technology and OR3O™ Dual Mobility System for total hip arthroplasty versus Cobalt Chrome liners

New data underscores material benefits of Smith+Nephew's OXINIUM™ DH Technology and OR3O™ Dual Mobility System for total hip arthroplasty versus Cobalt Chrome liners
prnewswire.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from prnewswire.com Daily Mail and Mail on Sunday newspapers.

United-kingdom , Adelaide , South-australia , Australia , Vasant-padmanabhan , Cozzi-lepri , Linkedin , Twitter , Oxinium-dh-technology , George-guild , Exchange-commission , Australian-orthopaedic-association-national-joint-replacement-registry

Frontiers | Increased Loading Rates During Gait Correlate With Morphology of Unaffected Hip in Juveniles With Treated Developmental Hip Dysplasia

Frontiers | Increased Loading Rates During Gait Correlate With Morphology of Unaffected Hip in Juveniles With Treated Developmental Hip Dysplasia
frontiersin.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from frontiersin.org Daily Mail and Mail on Sunday newspapers.

New-york , United-states , Helsinki , Eteläuomen-läi , Finland , United-kingdom , Acta-orthop , Acta-chir , Vicon-motion-systems-ltd , Ground-reaction-force-during-gait , Ibm , Pearson

Xương khớp Tâm An: Bí quyết đánh bại viêm khớp, thoái hóa khớp, thoát vị đĩa đệm

Xương khớp Tâm An: Bí quyết đánh bại viêm khớp, thoái hóa khớp, thoát vị đĩa đệm
doisongphapluat.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from doisongphapluat.com Daily Mail and Mail on Sunday newspapers.

Center-security , Oil-massage-to , Company-herb-address-village , Bone-joint , Addition-members , Special-member , Western-medicine , Sets-health , Oil-massage , Hormones-phone , மையம்-பாதுகாப்பு

CBS Evening News With Norah ODonnell-20191228-11:06:00

a very big storm and it's going to move across literally the skin problems; and severe bone joint, or muscle pain. whole country. are you ready? so first let's start where it is right now, embedded in the deep ask your doctor how prolia® can help strengthen your bones. southwest, but once it gets out into the plain states, it drawsh indulgent, delicious, irresistible., night; gu o midity. fancy feast makes delighting your cat delightfully easy. the jet dream diving south and like a see saw pulling warmth every recipe, every last detail. north, what goes up must come another fancy way to show your love. fancy feast. introducing savory centers. down on the western side. the collision zone is where we paté with a center of gravy! have the heavy rain and also the big-time thunderstorms. look at these temperatures. over the next couple of days we'll see as many as 100 record- warm temperatures and because of the collision, nashville 70, 61 in chicago, west of it in the 30s, that's why we're going to see the probability of strong to severe thunderstorms. so here we are tomorrow morning. the worst of the weather, wichita down to oklahoma city, abilene. north of that snow, heavy snow, from denver into the high plains, pierre, rapid city, also in fargo. and notice the snow sticks right there for literally about 48 hours or so. in the meantime, it's heavy rain, chicago, indianapolis, and maybe some strong storms

Storm , Doctor , Country , States , Bones , Prolia , The-deep-southwest , Guo-midity , It-drawsh , Feast , Skin-problems , Muscle-pain

ABC World News Tonight With David Muir-20191217-01:48:00

prolia® can cause serious side effects, like low blood calcium; serious infections which could need hospitalization; skin problems; and severe bone joint, or muscle pain. are you ready? ask your doctor how prolia® can help strengthen your bones. (danny) after a long day of hard work... ...you have to do more work? (vo) automatically sort your expenses and save over 40 hours a month. (danny) every day you're nearly fried to a crisp, professionally! (vo) you earned it, we're here to make sure you get it. quickbooks. backing you. skip to the good part with alka-seltzer plus. now with 25% more concentrated power. nothing works faster for powerful cold relief. oh, what a relief it is! so fast! most people think as a reliable phone company. but to businesses, we're a reliable partner. we keep companies ready for what's next. (man) we weave security into their business. (man) we weave security into their business. (man) we weave security into their business. (second man) virtualize their operations. (second man) virtualize their operations. (woman) and build ai customer experiences. (second woman) we also keep them ready for the next big opportunity. like 5g. like 5g.

Infections , Doctor , Blood , Calcium , Prolia , Skin-problems , Muscle-pain , Side-effects , Bone-joint , Hospitalization , Can , It

CNN Newsroom With Fredricka Whitfield-20191215-19:31:00

tell your doctor about dental problems as severe jaw bone problems may happen or new or unusual pain in your hip groin, or thigh, as unusual thigh bone fractures have occurred. speak to your doctor before stopping prolia® as spine and other bone fractures have occurred. prolia® can cause serious side effects, like low blood calcium; serious infections which could need hospitalization; skin problems; and severe bone joint, or muscle pain. are you ready? ask your doctor how prolia® can help strengthen your bones.

Problems , Doctor , Prolia , Jaw-bone-problems , Thigh-bone-fractures , Bone-fractures , Pain , Thigh , Side-effects , Hip-groin , Spine , Can

Fox and Friends Sunday-20191215-12:00:00

which could need hospitalization; skin problems; and severe bone joint, or muscle pain. are you ready? ask your doctor how prolia® can help strengthen your bones. ♪ ♪ have yourself a merry little christmas -- ♪ let your heart be light pete: it is the all-american christmas, and you know whose pick that is. ed: that is me. [laughter] why? rachel: listen -- pete: you've got a deep soul,. ed: ed you always want me to go more modern. pete: all the people watching right now are in bed, and they're going to stay in bed. rachel: you're so wrong, you're

Doctor , Skin-problems , Infections , Prolia , Muscle-pain , Bone-joint , Hospitalization , Have-yourselfa-merry-little-christmas , Bones , Heart , Me-ed , All-american-christmas