Get latest articles and stories on Health at LatestLY. Ageing results in an increase in a cellular signal necessary for the skeleton's development, which weakens bones, according to a new study in mice. The study, led by researchers from NYU Grossman School of Medicine, found that blocking the signaling pathway, called Notch, in aging skeletal stem cells caused a “massive increase” in bone mass and restored lost bone-healing ability during ageing. Health News | Inhibiting Aberrant Stem Cell Signals During Ageing Reduces Bone Loss: Study.