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This article from Merck outlines how tissue engineering and regenerative medicine are using bioprintingto expand research.

Free flap surgery is currently the only successful method used by surgeons to reconstruct critical-sized defects of the jaw, and is commonly used in patients who have had bony lesions excised due to oral cancer, trauma, infection or necrosis. However, donor site morbidity remains a significant flaw of this strategy. Various biomaterials have been under investigation in search of a suitable alternative for segmental mandibular defect reconstruction. Hydrogels are group of biomaterials that have shown their potential in various tissue engineering applications, including bone regeneration, both t...

Here we report on the development of a hybrid nanofibrous scaffold made from polyvinylidene fluoride (PVDF) nanofibers embedding zinc oxide nanorods (ZnOns), and poly(ε-caprolactone) (PCL) nanofibers incorporating dexamethasone (DEX)-loaded chitosan nanoparticles using dual-electrospinning method. Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), scanning electron microscopy (SEM), and tensile analysis were carried out for physiochemical characterization of the scaffolds, followed by DEX release profile. In addition, an MTT assay was conducted to assess the viability of...

Segmental mandibular defects are a common problem in head and neck surgery. Osseous free flap transfer has revolutionized mandibular reconstruction; however, donor site morbidity remains a significant problem. Bone tissue engineering (BTE) employs strategies for reconstructing critical-sized bone defects, improving the patients’ quality of life. Scaffolds employed for BTE must be mechanically stable, osseointegrate with neighboring bone, and promote osteogenesis. The need for modified, hybrid constructs with a diversity of favorable characteristics is essential. This review focuses on the re...