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"Hydrogel: A Potential Material for Bone Tissue Engineering Repairing t" by D. S.Abdullah Al Maruf, Yohaann Ali Ghosh et al.

Free flap surgery is currently the only successful method used by surgeons to reconstruct critical-sized defects of the jaw, and is commonly used in patients who have had bony lesions excised due to oral cancer, trauma, infection or necrosis. However, donor site morbidity remains a significant flaw of this strategy. Various biomaterials have been under investigation in search of a suitable alternative for segmental mandibular defect reconstruction. Hydrogels are group of biomaterials that have shown their potential in various tissue engineering applications, including bone regeneration, both through in vitro and in vivo pre-clinical animal trials. This review discusses different types of hydrogels, their fabrication techniques, 3D printing, their potential for bone regeneration, outcomes, and the limitations of various hydrogels in preclinical models for bone tissue engineering. This review also proposes a modified technique utilizing the potential of hydrogels combined with scaffolds ....

3d Printing , Bone Tissue Engineering , Andibular Defect ,

"ZnO-incorporated polyvinylidene fluoride/poly(ε-caprolactone) nanocomp" by Faegheh FotouhiArdakani, Mohammad Mohammadi et al.

Here we report on the development of a hybrid nanofibrous scaffold made from polyvinylidene fluoride (PVDF) nanofibers embedding zinc oxide nanorods (ZnOns), and poly(ε-caprolactone) (PCL) nanofibers incorporating dexamethasone (DEX)-loaded chitosan nanoparticles using dual-electrospinning method. Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), scanning electron microscopy (SEM), and tensile analysis were carried out for physiochemical characterization of the scaffolds, followed by DEX release profile. In addition, an MTT assay was conducted to assess the viability of mouse bone marrow-derived mesenchymal stem cells (mBMSCs) on the hybrid nanofibrous scaffold. Furthermore, the alkaline phosphatase (ALP) activity of mBMSCs was identified as an early sign of osteogenic differentiation. Our findings show that piezoelectric components improved the mechanical capabilities, and controlled release of DEX enhanced osteogenic differentiation. Overall, hybrid nanofibrou ....

Bone Tissue Engineering , Drug Delivery , Ybrid Scaffolds , Piezoelectric Scaffold ,

"Current and future perspectives on biomaterials for segmental mandibul" by D. S.Abdullah Al Maruf, Krishnan Parthasarathi et al.

Segmental mandibular defects are a common problem in head and neck surgery. Osseous free flap transfer has revolutionized mandibular reconstruction; however, donor site morbidity remains a significant problem. Bone tissue engineering (BTE) employs strategies for reconstructing critical-sized bone defects, improving the patients’ quality of life. Scaffolds employed for BTE must be mechanically stable, osseointegrate with neighboring bone, and promote osteogenesis. The need for modified, hybrid constructs with a diversity of favorable characteristics is essential. This review focuses on the recent progresses in modulating the physiochemical properties and applications of biomaterials in BTE in the context of mandibular segmental defect repair. ....

Bone Tissue Engineering , Andibular Bone Regeneration ,