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Updating Framingham CVD risk score using waist circumference and estimated cardiopulmonary function: a cohort study based on a southern Xinjiang population | BMC Public Health

To explore the association between waist circumference (WC), estimated cardiopulmonary function (eCRF), and cardiovascular disease (CVD) risk in southern Xinjiang. Update the Framingham model to make it more suitable for the southern Xinjiang population. Data were collected from 7705 subjects aged 30–74 years old in Tumushuke City, the 51st Regiment of Xinjiang Production and Construction Corps. CVD was defined as an individual's first diagnosis of non-fatal acute myocardial infarction, death from coronary heart disease, and fatal or non-fatal stroke. The Cox proportional hazards regression analysis was used to analyze the association between WC, eCRF and CVD risk. Restricted cubic spline plots were drawn to describe the association of the two indicators with CVD risk. We update the model by incorporating the new variables into the Framingham model and re-estimating the coefficients. The discrimination of the model is evaluated using AUC, NRI, and IDI metrics. Model ....

Omron Dalian Co Ltd , Tumushuke City , Xinjiang Production , Construction Corps , Xinjiang Uygur Autonomous Region , Third Division , Southern Xinjiang , Japanese Olympus , Biochemical Laboratory , First Affiliated Hospital , Shihezi University School , Ethics Committee , Bonferroni Correctedp Value , Area Under Curve , Net Reclassification Index , Integrated Discrimination Improvement ,

[Full text] Sinomenine Inhibits the Growth of Ovarian Cancer Cells Through the Sup

CDK1,
BUB1) play important roles in the progression of G2/M phase in the cell cycle.
30,31 Furthermore, real-time PCR analysis was used to verify the results of transcriptome sequencing and the results indicated that the expression trends of the top 18 ranked degree genes were consistent with those obtained by RNA-seq, suggesting that the RNA-seq data reliably reflected the gene expression alterations (Figure 4B). According to the RNA-seq and real-time PCR results, the expressions of cell cycle regulated genes, such as
CDK1,
PLK1, and
BUB1, were significantly decreased after sinomenine treatment. These results were also in accord with the cell phenotype experiments. ....

United States , San Diego , Dnasei Takara , Bioanalyser Agilent , Beckman Coulter Cyto , Transcriptome Library Construction , Proteintech Group , Network Analysis , Chinese Academy Of Sciences , Cell Signaling Technology , Stem Cell Bank , Shanghai Majorbio Bio Pharm Biotechnology Co Ltd , Cell Culture , Chinese Academy , Survival Rate Assay , Cell Proliferation , Yuxiu Biotech , Seq Transcriptome Library Construction , Illumina Hiseq , Thermo Scientific , Nanodrop Technologies , Low Range Ultra Agarose , Expression Analysis , Transcripts Per Kilobase , Digital Gene Expression , Bonferroni Correctedp Value ,