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Bou Farhat and Nassar on the Use of NGS Mutation Signature vs IHC for Identifying dMMR Tumors

Drs Nassar and Bou Farhat explain how tumor-only NGS could address the limitations of IHC testing for MMR mutation signatures across several tumor types.

Boston , Massachusetts , United-states , Connecticut , Yale-university , New-haven , Elias-bou-farhat , Courtney-flaherty , Amin-nassar , Bou-farhat , Linkedin , Department-of-medicine-at-brigham

Discordant dMMR/IHC Status Correlates With Improved Treatment Outcomes in CRC and Endometrial Cancer

Patients with mismatch repair–deficient, immunohistochemistry-intact colorectal cancer or endometrial cancer benefit from immune checkpoint inhibitors.

Dana-farber-cancer-institute , Massachusetts , United-states , Boston , Bou-farhat , Eliasj-bou-farhat , National-comprehensive-cancer-network , Practice-guidelines , Colorectal-cancer- , Endometrial-cancer , Immune-checkpoint-inhibitors , D

Complementary NGS Improves dMMR Detection With IHC in CRC and Endometrial Cancer

Amin Nassar, MD, and Elias Bou Farhat, MD, spotlight a study evaluating the accuracy and sensitivity of NGS mutation signature in assessing MMR status vs IHC testing.

United-states , American , Amin-nassar , Bou-farhat , Elias-bou-farhat , College-of-american-pathologists , D , Ngs-mutation-signature , Mmr-status , Ihc-testing , Next-generation-sequencing- , Immunohistochemistry-

More Cancer Patients Could Benefit From Immunotherapy, Study Suggests

Next-generation sequencing analysis suggests that revising cancer care guidelines could allow 6,000 more cancer patients each year to benefit from immunotherapy.

United-states , Bou-farhat , Amin-nassar , Elias-bou-farhat , Technology-network , Yale-cancer-center , Dana-farber-cancer-institute , Mass-general-brigham , Clinical-care-medicine ,

Promising Cancer Test May Expand Immunotherapy Benefits

Promising Cancer Test May Expand Immunotherapy Benefits
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United-states , Amin-nassar , Aminh-nassar , William-blair , Ursula-matulonis , Bou-farhat , Abdul-rafeh-naqash , Elio-adib , Lynettem-sholl , Elias-bou-farhat , Melissa-daou , Davidj-kwiatkowski