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Tafenoquine following G6PD screening versus primaquine for the treatment of vivax malaria in Brazil: A cost-effectiveness analysis using a transmission model

Author summary Why was this study done? Radical cure with primaquine or recently approved tafenoquine is required to clear the dormant liver parasites of vivax malaria. While single-dose tafenoquine overcomes the barrier of patient adherence to the current 7-day primaquine treatment, it costs more and requires screening for glucose-6-phosphate dehydrogenase (G6PD) deficiency. While the impact of changing policies to tafenoquine after G6PD screening on transmission has been evaluated, the associated costs and cost-effectiveness will be important considerations for policymakers. What did the researchers find? Using an economic evaluation model coupled with a transmission model, we found that prescribing tafenoquine to vivax malaria patients without G6PD deficiency would be highly likely to be cost-effective in Brazil. Tafenoquine will be particularly cost-effective in settings where patient adherence to the current 7-day treatment is low and when paediatric tafenoquine is available ....

Papua New Guinea , United States , South Korea , Republic Of Korea , Monte Carlo , Jamesg Beeson , Brazilian Unified Health System , National Malaria Control Programme , Ministry Of Health Brazil , Burnet Institute , Technological Development Cnpq , World Health Organisation , Melinda Gates Foundation , National Council For Scientific , National Commission For The Incorporation Of Technologies , Ministry Of Health , National Malaria Prevention , Creative Commons Attribution License , National Council , Technological Development , United States Dollars , South America , While Scenarios , Epidemiological Surveillance Information System , National Commission , Brazilian Unified Health ,

Vision Loss Will Increase in Brazil, Russia, India, China, South Africa by 2040

By 2040, the number of blindness and vision loss cases are estimated to increase by roughly 50% across Brazil, Russia, India, China, and South America, a new study found. ....

South Africa , Jianqi Chen , Brazilian Unified Health System , State Key Laboratory , Sun Yatsen University , Global Burden , Vision Loss ,