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Research Uncovers Why Lupus is More Prevalent in Women

Research Uncovers Why Lupus is More Prevalent in Women
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Why lupus is more prevalent among women

Why lupus is more prevalent among women
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Researchers explore origins of lupus, find reason for condition's prevalence among women

Researchers explore origins of lupus, find reason for condition's prevalence among women
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Muscle Protein That Makes Vertebrates More Fit Linked to Limited Lifespan

Muscle Protein That Makes Vertebrates More Fit Linked to Limited Lifespan
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Molecular alteration may be cause -- not consequence -- of heart failure


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Clinicians and scientists have long observed that cells in overstressed hearts have high levels of the simple sugar O-GlcNAc modifying thousands of proteins within cells. Now, researchers at Johns Hopkins Medicine have found evidence in mouse experiments that these excess sugars could well be a cause, not merely a consequence or marker of heart failure.
Their research found that elevated levels of O-GlcNAc made mice more prone to heart failure, but lowering levels of O-GlcNAc restored the animals' risk of death and heart function to normal. Together, the investigators say, the new findings, described online in the April 27th issue of the journal

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Gut microbe may promote breast cancers


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A microbe found in the colon and commonly associated with the development of colitis and colon cancer also may play a role in the development of some breast cancers, according to new research from investigators with the Johns Hopkins Kimmel Cancer Center and its Bloomberg~Kimmel Institute for Cancer Immunotherapy. Breast tissue cells exposed to this toxin retain a long-term memory, increasing the risk for disease.
In a series of laboratory experiments, researchers discovered that when enterotoxigenic Bacteroides fragilis (ETBF) was introduced to the guts or breast ducts of mice, it always induced growth and metastatic progression of tumor cells. A description of the work is published in the January 6 issue of the journal

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