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The five-story addition will expand the Jacksonville campus building to 13 floors, part of a $432 million project.
This week's building permits feature Bank of America, the Jacksonville Jaguars, MIller Electric, Mayo Clinic, the JTA and Farah & Farah.
The city approved a permit for the $2.52 million first-floor renovations of the public area.
Mayo Clinic announced plans to add five floors to the top of its main hospital on the Jacksonville campus, expanding to 13 floors with 121 new beds.
The medical system said the 13-floor tower will add 121 inpatient beds and be completed by the end of 2026.