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Synthetic antibiotic could be effective again

A scientific journey decades in the making has found a new antibiotic strategy to defeat gram-negative bacteria like Salmonella, Pseudomonas and E. coli, the culprits in many urinary tract infections. The synthetic molecule works fast and is durable. It interferes with synthesis of the bacterial outer membrane by jamming an enzyme. When tested against a clinical collection of 285 bacterial strains, including some that were highly resistant to commercial antibiotics, it killed them all. ....

North Carolina , United States , Duke University , Carly Sciandra , Robert Nicholas , Ivan Spasojevic , Javaria Najeeb , Kate Newns , Eric Toone , Clayton Duncan , David Gooden , Ivan Spasojevic Duke , Joshua Thaden , Nadine Lemaitre , Richard Gammans , Christian Raetz , Jinshi Zhao , Pei Zhou , Florent Sebbane , Vance Fowler , Ziqiang Guan , Method Of Research , University Of Lille , Carolina Biotechnology Center , Merck Co , Joshua Thaden Duke School Of Medicine ,

Synthetic antibiotic could be effective again

A scientific journey decades in the making has found a new antibiotic strategy to defeat gram-negative bacteria like Salmonella, Pseudomonas and E. coli, the culprits in many urinary tract infections. The synthetic molecule works fast and is durable. It interferes with synthesis of the bacterial outer membrane by jamming an enzyme. When tested against a clinical collection of 285 bacterial strains, including some that were highly resistant to commercial antibiotics, it killed them all. ....

North Carolina , United States , Duke University , Jinshi Zhao , Robert Nicholas , Richard Gammans , Pei Zhou , Florent Sebbane , Christian Raetz , Carly Sciandra , Kate Newns , Clayton Duncan , Ivan Spasojevic Duke , David Gooden , Ziqiang Guan , Eric Toone , Nadine Lemaitre , Javaria Najeeb , Joshua Thaden , Ivan Spasojevic , Vance Fowler , Carolina Biotechnology Center , Method Of Research , Joshua Thaden Duke School Of Medicine , National Institutes Of Health , University Of Lille ,