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Researchers uncover new therapeutic vulnerability in endocrine therapy-resistant breast cancers

For patients with estrogen receptor (ER)-positive breast cancer, development of the so-called Y537S mutation signals that their disease has taken an aggressive course and may become resistant to endocrine therapy. ....

Karla Parra , Mia Hofstad , Qian Wang , Shuguang Wei , Brucea Posner , Emily Henderson , Prasanna Alluri , Ganeshv Raj , Yulun Liu , Jayeshk Sharma , Sophie Geboers , Noelles Williams , Venkats Malladi , Breast Cancer Research Foundation , Ut Southwestern Medical Center , Department Of Defense Breast Cancer Research Program , Haroldc Simmons Comprehensive Cancer Center , Cary Council Of Southwestern Medical Foundation , Cancer Foundation , Medical Center , Assistant Professor , Radiation Oncology , Comprehensive Cancer Center , Srinivas Malladi , Conquer Cancer Foundation , Cary Council ,

Drug shows promise in overcoming endocrine therapy resistance in breast cancer

DALLAS – Nov. 15, 2022 – For patients with estrogen receptor (ER)-positive breast cancer, development of the so-called Y537S mutation signals that their disease has taken an aggressive course and may become resistant to endocrine therapy. ....

United States , Karla Parra , Mia Hofstad , Qian Wang , Shuguang Wei , Brucea Posner , Prasanna Alluri , Ganeshv Raj , Yulun Liu , Jayeshk Sharma , Sophie Geboers , Venkats Malladi , Noelles Williams , Breast Cancer Research Foundation , Department Of Defense Breast Cancer Research Program , Southwestern Medical Center , Haroldc Simmons Comprehensive Cancer Center , Cary Council Of Southwestern Medical Foundation , Cancer Foundation , Assistant Professor , Radiation Oncology , Comprehensive Cancer Center , Srinivas Malladi , Conquer Cancer Foundation , Cary Council , Southwestern Medical Foundation ,