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Blood-brain barrier breakdown in multiple sclerosis leads to immune cell infiltration into the central nervous system. Antigen presentation at the barrier promotes CD8+ T cell entry, triggering focal breakdown and hindering their invasion.
Researchers from the Cima University of Navarra (Spain) have presented the results of an international competition initiated ten years ago to improve the study of cell migration.
Immunotherapy, particularly CAR T-Cell treatment for cancer, is extending the lives of many patients. But sometimes the therapy randomly migrates to places it shouldn't go, tucking into the lungs or other noncancerous tissue and causing toxic side effects.
In this article, Sartorius writes about a novel way by which to conduct dynamic quantification of cell migration in a real-time setting.
A study published in the Journal of Nutritional Biochemistry investigated the changes in gene expressions during an overfeeding episode. It demonstrated that supplementation of grape polyphenols in healthy lean men modulates the expression of genes related to adipose tissue angiogenesis.