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Identifying UCHL1 as a positive regulator of M1 macrophage polarization

Summarizing the various roles of exosomal miRNAs and circulating miRNAs in gestational diabetes mellitus

Covering the preclinical and clinical literature supporting the role of melatonin in the management of brain injury-induced oxidative stress

163 are also involved in resistance to cisplatin, temozolomide and 5-fluorouracil via altering glycolysis in gastric cancer, glioblastoma and CRC, respectively. Interestingly, Fu et al reported that lncRNA plasmacytoma variant translocation 1 (PVT1) maintains Myc expression in Sjögren’s syndrome. This expression regulates proliferation and immune effects of CD4 + T cells by controlling glycolytic metabolism. 164 Investigating the role of the PVT1-T cell glycolysis axis in tumor models may provide a novel insight for improving T cell-based immunotherapy. The important role of lncRNAs-mediat...

* 1Division of Cardiovascular Disease, Department of Medicine, The University of Alabama at Birmingham, Birmingham, AL, United States 2Molecular and Cellular Pathology, Department of Pathology, The University of Alabama at Birmingham, Birmingham, AL, United States 3Department of Biomedical Engineering, The University of Alabama at Birmingham, Birmingham, AL, United States 4Center for Translational Medicine, Temple University, Philadelphia, PA, United States Background: Endothelial cells (ECs) play a critical role in the maintenance of vascular homeostasis and in heart function. It was shown t...