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Two Major Studies Have Connected One Key Hormone to Breast Cancer CLARE WATSON 27 APRIL 2021 An unusual but ubiquitous hormone called prolactin, which plays a vital role in producing milk during pregnancy, could also be a major driver of breast cancer, two new studies have shown.
The findings are the latest in a long line of research from a lab led by cancer pathologist Charles Clevenger from Virginia Commonwealth University, who has been trying to untangle prolactin s precise role in breast cancer ever since he discovered the first evidence that the growth factor could be involved in the disease midway through the 1990s. ....
Prolactin hormone acts as a major contributor to breast cancer development, studies find news-medical.net - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from news-medical.net Daily Mail and Mail on Sunday newspapers.
Credit: VCU Massey Cancer Center The hormone prolactin has long been understood to play a vital role in breast growth and development and the production of milk during pregnancy. But a pair of recent studies conducted at VCU Massey Cancer Center finds strong evidence that prolactin also acts as a major contributor to breast cancer development and that the hormone could inform the creation of targeted drugs to treat multiple forms of the disease. Hormones have proteins on their cell surface called receptors that receive and send biological messages and regulate cell function. Through research published in npj Breast Cancer, VCU Massey Cancer Center researcher Charles Clevenger, M.D., Ph.D., and his lab discovered a new, altered form of the prolactin receptor called the human prolactin receptor intermediate isoform (hPRLrI) that directly drives breast cancer. The researchers observed that this modified version of the prolactin receptor interacted with other forms of the ....
Charles Clevenger, the first director of the Dixon University Center, dies at 79 Updated Apr 15, 2021; The death followed a six-year battle with brain cancer, his obituary said. Clevenger was a Brooklyn native who began his career as an editor and writer while earning his master’s and doctoral degrees through The State University of New York system. In 1984 he accepted the position of dean of the College of Education and Human Services at Shippensburg University and moved his family to Carlisle. In 1993, the center’s board of governors recognized the leadership and generosity of its founding chairman, F. Eugene Dixon Jr., by renaming it in his honor. Clevenger would become the Dixon University Center’s first director. ....