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New agonistic antibody reduced the amyloid pathology in mice with Alzheimer's disease

A newly developed agonistic antibody reduced the amyloid pathology in mice with Alzheimer's disease, signaling its promise as a potential treatment for the disease, according to a team of researchers at UTHealth Houston. ....

United States , Peng Zhao , Baylor College Of Medicine , Phyllis Gough Huffington , Wei Cao , Yingjun Zhao , Emily Henderson , Ningyan Zhang , Yuanzhong Xu , Lulin Jiang , Hui Zheng , Xin Li , Leike Li , Hisashi Arase , Huaxi Xu , Roberta Welch Distinguished University , Welch Foundation , Sanford Burnham Prebys Medical Discovery Institute , Osaka University , Mcgovern Medical School , Chemistry At Mcgovern Medical School , Texas Therapeutics Institute , Research Institute Of Texas , Xiamen University , Distinguished University Chair , Science Translational ,

Study: Agonistic antibody works as a potential therapy in mice with Alzheimer's disease

A recently created agonistic antibody reduced amyloid pathology in mice with Alzheimer disease, indicating its potential as a therapy for the condition, accor ....

United States , Ningyan Zhang , Mcgovern Medical School , Chemistry At Mcgovern Medical School , Texas Therapeutics Institute , Roberta Welch Distinguished University , Distinguished University Chair , Science Translational , Brown Foundation Institute , Molecular Medicine , Human Diseases , Mcgovern Medical , Science News , Mcgovern Medical , Mice With , Gonistic Antibody , Antibody Based ,

Study: Nasal therapy is more effective than commonly used IgG antibodies at neutralizing COVID-19 virus

A nasal therapy, built upon on the application of a new engineered IgM antibody therapy for COVID-19, was more effective than commonly used IgG antibodies at neutralizing the COVID-19 virus in animal models, according to research recently published by The University of Texas Health Science Center at Houston (UTHealth), The University of Texas Medical Branch at Galveston (UTMB Health), the University of Houston, and IGM Biosciences, Inc. ....

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Preclinical research reveals that new IgM antibodies administered intranasally to fight COVID-19 more potent than commonly used ones

A nasal therapy, built upon on the application of a new engineered IgM antibody therapy for COVID-19, was more effective than commonly used IgG antibodies at neutralizing the COVID-19 virus in animal models, according to research recently published by The University of Texas Health Science Center at Houston (UTHealth), The University of Texas Medical Branch at Galveston (UTMB Health), the University of Houston, and IGM Biosciences, Inc. ....

South Africa , University Of Houston , United States , University Of Texas , South African , Stephenf Carroll , Vineetd Menachery , Xinli Liu , Sujit Biswas , Ningyan Zhang , Junquan Liu , Paulr Hinton , Elizabethj Haanes , Brucea Keyt , Chui Deng , Yang Liu , Xuping Xie , Zhiqiang Ku , Pei Yong Shi , Antonioe Muruato , Kevinb Carlin , Jing Zou , Deepal Pandya , Wei Xiong , Sachi Rahman , Fred Schwarzer ,

Why some cancer drugs may be ineffective

By
Sun Apr 18 2021
A possible explanation for why many cancer drugs that kill tumor cells in mouse models won’t work in human trials has been found.

A possible explanation for why many cancer drugs that kill tumor cells in mouse models won’t work in human trials has been found by researchers with The University of Texas Health Science Center at Houston (UTHealth) School of Biomedical Informatics and McGovern Medical School.
The research was published today in Nature Communications.
In the study, investigators reported the extensive presence of mouse viruses in patient-derived xenografts (PDX). PDX models are developed by implanting human tumor tissues in immune-deficient mice, and are commonly used to help test and develop cancer drugs. ....

United States , Wuhua Xu , W Jim Zheng , Uthealth Neurosciences , Jay Jiguang Zhu , Ningyan Zhang , Jiaqian Wu , Ming Fu , Nature Communications , School Of Biomedical Informatics , Informatics Core For Cancer Research , Texas Therapeutic Institute , National Institutes Of Health , Roberta Welch Distinguished University , Institute Of Molecular Medicine , Welch Foundation , Mcgovern Medical School , Chemistry At Mcgovern Medical School , School Of Biomedical Informatic , Texas Therapeutics Institute , Research Institute Of Texas , Texas Health Science Center , Biomedical Informatics , Mcgovern Medical , Molecular Medicine , Data Science ,