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Crick Researchers make key DNA discovery

A collaborative study by researchers at the Francis Crick Institute has uncovered how the double helix structure of DNA is opened to allow DNA replication, essential for enabling processes including DNA repair, gene expression and replication of DNA for cell division to occur. Click to read more. ....

John Diffley , Jacob Lewis , Macromolecular Machines Laboratory , Structural Biology Science Technology Platform , Francis Crick Institute , Chromosome Replication Laboratory , Postdoctoral Training Fellow ,

Large-scale drug analysis reveals potential new COVID-19 antivirals

Large-scale drug analysis reveals potential new COVID-19 antivirals
ANI |
Updated: Jul 04, 2021 08:14 IST
London [UK], July 4 (ANI): Researchers at the Francis Crick Institute and University of Dundee have screened thousands of drug and chemical molecules and identified a range of potential antivirals that could be developed into new treatments for COVID-19 or in preparation for future coronavirus outbreaks.
In a series of seven papers, published in the Biochemical Journal, the scientists identified 15 molecules that inhibit the growth of SARS-CoV-2 by blocking different enzymes involved in its replication.
While COVID-19 vaccines are being rolled out, there are still few drug options that can be used to treat patients with the virus, reduce symptoms and speed up recovery time. These treatments are especially important for groups where the vaccines are less effective, such as some patients with blood cancers. ....

City Of , United Kingdom , John Diffley , Francis Crick Institute , Chromosome Replication Laboratory , University Of Dundee , Biochemical Journal , High Throughput Screening , நகரம் ஆஃப் , ஒன்றுபட்டது கிஂக்டம் , ஜான் டிஃப்லி , பிரான்சிஸ் கிரிக் நிறுவனம் , பல்கலைக்கழகம் ஆஃப் டண்டீ , உயிர்வேதியியல் இதழ் ,

Potential COVID-19 antivirals discovered

Potential COVID-19 antivirals discovered
04 Jul 2021, 13:03 GMT+10
London [UK], July 4 (ANI): Researchers at the Francis Crick Institute and University of Dundee have screened thousands of drug and chemical molecules and identified a range of potential antivirals that could be developed into new treatments for COVID-19 or in preparation for future coronavirus outbreaks.
In a series of seven papers, published in the Biochemical Journal, the scientists identified 15 molecules that inhibit the growth of SARS-CoV-2 by blocking different enzymes involved in its replication.
While COVID-19 vaccines are being rolled out, there are still few drug options that can be used to treat patients with the virus, reduce symptoms and speed up recovery time. These treatments are especially important for groups where the vaccines are less effective, such as some patients with blood cancers. ....

City Of , United Kingdom , John Diffley , Francis Crick Institute , Chromosome Replication Laboratory , University Of Dundee , Biochemical Journal , High Throughput Screening , நகரம் ஆஃப் , ஒன்றுபட்டது கிஂக்டம் , ஜான் டிஃப்லி , பிரான்சிஸ் கிரிக் நிறுவனம் , பல்கலைக்கழகம் ஆஃப் டண்டீ , உயிர்வேதியியல் இதழ் ,

Large-scale drug analysis reveals potential new COVID-19 antivirals

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Researchers at the Francis Crick Institute and University of Dundee have screened thousands of drug and chemical molecules and identified a range of potential antivirals that could be developed into new treatments for COVID-19 or in preparation for future coronavirus outbreaks.
While COVID-19 vaccines are being rolled out, there are still few drug options that can be used to treat patients with the virus, to reduce symptoms and speed up recovery time. These treatments are especially important for groups where the vaccines are less effective, such as some patients with blood cancers.
In a series of seven papers, published today (2 July) in the ....

United Kingdom , City Of , John Diffley , King College London , University College London , Chromosome Replication Laboratory , Imperial College London , Cancer Research United Kingdom , Biochemical Society , Francis Crick Institute , Research Council , University Of Dundee , Biochemical Journal , High Throughput Screening , Small Molecule Inhibitors , Medical Research Council , Portland Press , ஒன்றுபட்டது கிஂக்டம் , நகரம் ஆஃப் , ஜான் டிஃப்லி , கிங் கல்லூரி லண்டன் , பல்கலைக்கழகம் கல்லூரி லண்டன் , ஏகாதிபத்தியம் கல்லூரி லண்டன் , புற்றுநோய் ஆராய்ச்சி ஒன்றுபட்டது கிஂக்டம் , உயிர்வேதியியல் சமூகம் , பிரான்சிஸ் கிரிக் நிறுவனம் ,

Inhibition of nsp14 methyltransferase as a potential antiviral target for SARS-CoV-2

Beyond vaccination, the broad-spectrum antiviral medication remdesivir has robust clinical evidence and is known as the best antiviral treatment to reduce severe COVID-19 infection in hospitalized patients. Research led by John F.X. Diffley of the Chromosome Replication Laboratory suggests a potential therapeutic target for treatment development is the viral RNA cap methyltransferases, essential for viral protein translation and immune evasion. ....

Johnfx Diffley , Jocelyn Solis Moreiraapr , Jocelyn Solis Moreira , Chromosome Replication Laboratory , Small Molecule Inhibitors , Image Credit , Sars Cov 2 , Corona Virus , In Vitro , Mammalian Cells , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , ஜாஸ்லைந் ஸோலிஸ் மோர்ர , படம் கடன் , கொரோனா வைரஸ் , இல் விட்ரோ , கடுமையானது எடுப்போசை சுவாச , கடுமையானது எடுப்போசை சுவாச நோய்க்குறி ,