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A Washington University School of Medicine in St. Louis study may help explain how excess weight can contribute to diabetes and may provide researchers with a target to help prevent or delay diabetes in some of those at risk. The findings suggest that many people with elevated levels of insulin also have defects in an enzyme important to the processing of a key fatty acid.
Semenkovich.Many at risk for diabetes have elevated levels of insulin, a hallmark of insulin resistance and a signal that means trouble may be brewing.If we could intervene before they actually develop diabetes, we might be able to prevent significant health problems - such as heart disease, chronic kidney disease, nerve damage, vision loss and other problems - in a great number of people, said Semenkovich.According to the study, when a person has too much body fat, it signals beta cells in the pancreas to secrete more insulin.
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Kilo Charles J. Kilo, MD, a former professor of clinical medicine in the Division of Endocrinology, Metabolism & Lipid Research at Washington University School of Medicine in St Louis, died of pneumonia March 15, 2021, in Naples, Fla. He was 94. Kilo and collaborators at the School of Medicine were among the first to demonstrate that diabetes complications are linked to the duration of the disease and the degree of blood sugar control. An early advocate for aggressive monitoring and control of blood glucose, Kilo challenged past treatment methods and the safety of blood glucose lowering agents. He pushed for regular measurement of glycated hemoglobin to track glucose levels in the blood. In subsequent years, measurement of so-called hemoglobin A1c became the standard in diabetes care.