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High comorbidity burden among men with subsequent osteoporotic fractures

SEATTLE — Among men aged at least 40 years who experienced a fracture, most with subsequent fractures in the next 2 years had cardiometabolic comorbidities and used medications linked to increased fall risk, according to researchers. “The recognition of associated risk factors can help identify individuals at high risk for subsequent fracture,” Ruban Dhaliwal, MD, MPH, associate ....

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Scholar Rock Reports First Quarter 2023 Financial Results and Highlights Business Progress

- Enrollment of pivotal Phase 3 SAPPHIRE trial evaluating apitegromab on track for completion in 2023

- Upcoming presentations of 36-month apitegromab data from Phase 2 TOPAZ trial at Cure. | May 9, 2023 ....

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PTH therapy cuts need for calcium, vitamin D supplements for most with hypoparathyroidism

SEATTLE — Most adults with hypoparathyroidism no longer needed calcium or vitamin D supplementation after initiating a once-daily active parathyroid hormone drug, according to a speaker.
Palopegteriparatide (TransCon PTH, Ascendis Pharma) is an investigational once-daily prodrug with sustained release of active PTH. The agent is being developed as a potential treatment for ....

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Personalized approach emphasized in AACE consensus statement for treating type 2 diabetes

SEATTLE — Providers treating people with type 2 diabetes should take a complication-centric approach for determining first-line pharmacotherapy, according to a consensus statement. An update to AACE’s Comprehensive Type 2 Diabetes Management Algorithm was published in Endocrine Practice and discussed during a plenary talk at the AACE Annual Scientific and Clinical Conference. The ....

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Adults diagnosed with myxedema coma have increased mortality risk, longer hospital stay

SEATTLE — Hospitalized adults with hypothyroidism who are diagnosed with myxedema coma have a higher mortality rate and are hospitalized for longer than those without myxedema coma, according to a speaker. “Although decompensated hypothyroidism, often called myxedema coma, is recognized as an emergent condition with high mortality, its rarity prevents robust analysis of its ....

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