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Obesity is a risk factor for cognitive dysfunction and neurodegenerative disease, including Alzheimer's disease (AD). The gut microbiota-brain axis is altered in obesity and linked to cognitive impairment and neurodegenerative disorders. Here, we targeted obesity-induced cognitive impairment by testing the impact of the probiotic Clostridium butyricum, which has previously shown beneficial effects on gut homeostasis and brain function. Firstly, we characterized and analyzed the gut microbial profiles of participants with obesity and the correlation between gut microbiota and cognitive scores. Then, using an obese mouse model induced by a Western-style diet (high-fat and fiber-deficient diet), the effects of Clostridium butyricum on the microbiota-gut-brain axis and hippocampal cognitive function were evaluated. Finally, fecal microbiota transplantation was performed to assess the functional link between Clostridium butyricum remodeling gut microbiota and hippocampal synaptic prote ....
One person has died and eight people have been hospitalized after an outbreak of botulism in a restaurant in the French city of Bordeaux, according to a statement from France’s public health body on Wednesday. ....
/PRNewswire/ On 12 July 2022, Menet held the award ceremony of the "Annual Top 100 China s Pharmaceutical Entreprises in 2021", in which 5 sub-lists of the. ....