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Promising breakthroughs ignite hope for a novel and effective Tuberculosis vaccine

The success and challenges of developing different tuberculosis (TB) vaccine types. ....

South Africa , Bacille Calmette Gu , Robert Koch , Npj Vaccinesstudy , Diversity Outbred , Collaborative Cross , Bcg Vaccine , Clinical Trial ,

Unraveling the genetic factors behind faulty insulin secretion

A study of the genetic variations that underlie differences in insulin secretion in mice has identified a number of candidate genes that may drive the development of conditions such as type 2 diabetes. ....

United States , University Of Wisconsin , Chris Emfinger , Christopherh Emfinger , Lauren Clark , Christopher Emfinger , Department Of Biochemistry , Life Reviewed Preprint , Collaborative Cross , Diversity Outbred , Graduate Student , Special Issue ,

NIH grant awarded to Marshall researcher for studying genetic mechanisms of cocaine addiction

Price E. Dickson, Ph.D., an assistant professor of biomedical sciences at the Marshall University Joan C. Edwards School of Medicine, has received a $407,000 grant from the National Institutes of Health to study the genetic and genomic mechanisms driving the relationship between social reward and cocaine addiction. ....

United States , Shelley Moore Capito , Joe Manchin , Emily Henderson , Jackson Laboratory In Bar Harbor , School Of Medicine , National Institute On Drug Abuse , National Institutes Of Health , Marshall University Joan , National Institutes , Collaborative Cross , National Institute , Drug Abuse , Jackson Laboratory , Bar Harbor ,

Sarbecovirus pathogenesis regulated by a multitrait locus

In a recent study posted to the bioRxiv preprint server, the authors demonstrated that the sarbecovirus pathogenesis was regulated by a multitrait locus. ....

Multitrait Locus Regulates Sarbecovirus , Image Credit , Collaborative Cross , Coronavirus Disease Covid 19 , Covid 19 , Ene Expression , Infectious Diseases , Ars Cov 2 ,

Research reveals the mechanisms of cardiac sex disparities at an early stage

Males and females differ in prevalence, treatment responses, and survival rates for a variety of diseases. For cardiac disease, women almost uniformly fare far worse than men. There are likely many reasons for this, and scientists at the University of North Carolina at Chapel Hill and Princeton University seemed to have found one deep inside cells before we're even born. ....

Wei Shi , Henryl Hillman , Xinlei Sheng , Ileana Cristea , Emily Henderson , School Of Medicine , Princeton University , University Of North Carolina , University Of North Carolina At Chapel Hill , Study Co , Mcallister Heart Institute , Development Cell , National Heart , North Carolina , Chapel Hill , Conlon Phd , Study Co Senior Author , Molecular Biology , Blood Institute Working Group , Sex Differences Research , Collaborative Cross , Allister Heart , Heart Disease , Protein Expression ,