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Good and bad memories have their own real estate - Vimarsana News

Good and bad memories have their own real estate

Knowing where positive and negative memories are stored in the brain opens the door to manipulating networks of specific neurons.

West Nile Virus circulation in Portugal concentrated in south, study finds - Vimarsana News

West Nile Virus circulation in Portugal concentrated in south, study finds

Researchers say more active surveillance will be required to keep watch on the virus, which can infect horses and humans.

Frontiers | The One That Got Away: How Macrophage-Derived IL-1β Escapes the Mycolactone-Dependent Sec61 Blockade in Buruli Ulcer - Vimarsana News

Frontiers | The One That Got Away: How Macrophage-Derived IL-1β Escapes the Mycolactone-Dependent Sec61 Blockade in Buruli Ulcer

Buruli ulcer (BU), caused by Mycobacterium ulcerans, is a devastating necrotizing skin disease. Key to its pathogenesis is mycolactone, the exotoxin virulence factor that is both immunosuppressive and cytotoxic. The discovery that the essential Sec61 translocon is the major cellular target of mycolactone explains much of the disease pathology, including the immune blockade. Sec61 inhibition leads to a loss in production of nearly all cytokines from monocytes, macrophages, dendritic cells and T cells, as well as antigen presentation pathway proteins and costimulatory molecules. However, there h...