Testosterone-replacement therapy noninferior to placebo for preventing cardiovascular events
1. In this randomized controlled trial, in adults with hypogonadism and cardiovascular risk factors, testosterone did not reduce the incidence of major adverse cardiac events (MACE) compared to a control. 2. Arrhythmias, atrial fibrillation, acute kidney injury, and pulmonary embolism occurred more frequently in the testosterone group. Evidence Rating Level: 1 (Excellent) Study Rundown: Male