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FDA approves Melinta's Kimyrsa for skin infections Melinta Therapeutics of Morristown, New Jersey, announced yesterday that the US Food and Drug Administration (FDA) has approved Kimyrsa (oritavancin) for treatment of adult patients with acute bacterial skin and skin-structure infections (ABSSSIs) caused by susceptible gram-positive pathogens, including methicillin-resistant Staphylococcus aureus (MRSA). Kimyrsa delivers a complete course of the lipoglycopeptide antibiotic oritavancin in a single, 1-hour 1,200 milligram (mg) intravenous infusion. The drug is an updated version of Orbactiv, w...

Stewardship intervention linked to more appropriate ER prescribing A multifaceted intervention implemented in a Japanese emergency department was associated with reduced antibiotic prescribing at discharge and an increase in appropriate prescribing, Japanese researchers reported today in Infection Control and Hospital Epidemiology. In a before-and-after study conducted at a tertiary-care center in Tokyo, hospital researchers compared the average monthly proportion of appropriate antimicrobial prescriptions at discharge (APD), and the average rate of monthly APD per 1,000 visits, in the year ...