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 E-Mail IMAGE: Scientists from Japan have developed novel hydrogels to effectively deliver drugs to tumor sites in response to temperature and pH changes in the tumor microenvironment view more  Credit: Tokyo University of Science Cancer therapy in recent times relies on the use of several drugs derived from biological sources including different bacteria and viruses, among others. However, these bio-based drugs get easily degraded and therefore inactivated on administration into the body. Thus, effective delivery to and release of these drugs at target tumor sites are of paramount ...

In a study reported in the  Journal of Controlled Release, researchers from Okayama University describe the use of nanocarriers in selectively transporting anticancer drugs to brain tumors. Glioblastoma is an aggressive form of brain cancer that is best treated with boron neutron capture therapy (BNCT). BNCT involves the use of an agent that delivers boron into tumor tissues. When subsequently hit with radiation, boron (typically the 10B isotope is used) emits particles that kill neighboring cells. However, current methods do not cargo boron into cancer cells homogenously. Now, Associate pro...

Researchers develop ultra-small nanomedicines to target intractable cancers Ultra-small nanomedicines of approximately 18 nm were fabricated by dynamic ion-pairing between Y-shaped block copolymers and nucleic acid drugs, such as siRNA and antisense drugs. Chemically modified and double-stranded oligonucleotides dramatically enhanced the stability of the ultra-small nanomedicines in the blood circulation. The ultra-small size allows for high permeability in cancer tissues by slipping through the cracks in tumor vasculatures and stromal tissues. Clinical trials and preclinical studies using th...

Loading video... VIDEO: Nanomedicines consisting of one molecule of oligonucleotide and one or two molecules of Y-shaped block copolymer(s), of which the size is approximately 18 nm and is in dynamic equilibrium with free Y-shaped... view more  Credit: 2021 Innovation Center of NanoMedicine Summary Ultra-small nanomedicines of approximately 18 nm were fabricated by dynamic ion-pairing between Y-shaped block copolymers and nucleic acid drugs, such as siRNA and antisense drugs. Chemically modified and double-stranded oligonucleotides dramatically enhanced the stability of the ultra-smal...

 E-Mail DURHAM, N.C. - A Duke-led team of scientists has developed a bio-compatible surgical patch that releases non-opioid painkillers directly to the site of a wound for days and then dissolves away. The polymer patch provides a controlled release of a drug that blocks the enzyme COX-2 (cyclooxygenase-2,) which drives pain and inflammation. The study appears Jan. 10, 2021 in the Journal of Controlled Release. When they started "We were making hernia meshes and different antimicrobial films," said Matthew Becker, the Hugo L. Blomquist professor chemistry at Duke, and last author on the p...