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Polycomb complexes found to be essential for proper skin development Mount Sinai researchers have discovered that Polycomb complexes, groups of proteins that maintain gene expression patterns, are essential for proper skin development, according to a paper published in Genes & Development on February 18. This latest discovery could improve development of future stem cell therapies to generate "skin on a dish" to transplant into burn victims and patients with skin-blistering disorders. Polycomb complexes are groups of proteins that maintain the gene-expression patterns during early developmen...

ABSTRACT Current approaches to coat aluminum surfaces that use paints and organic coatings to protect them from corrosion and provide an aesthetic finish, are also energy intensive and involve high emissions of VOCs.  The use of these coatings is becoming increasingly restricted by global efforts towards more environmentally sustainable surface finishing technologies.  A recent development based on porous anodized aluminum (PAA) and metal nanowire deposits is presented here, which may become a competitive alternative to paint and organic coatings.  Anodizing and electrodeposition do not em...

Major antioxidant in green tea may increase levels of natural anti-cancer protein An antioxidant found in green tea may increase levels of p53, a natural anti-cancer protein, known as the "guardian of the genome" for its ability to repair DNA damage or destroy cancerous cells. Published today in Nature Communications, a study of the direct interaction between p53 and the green tea compound, epigallocatechin gallate (EGCG), points to a new target for cancer drug discovery. Both p53 and EGCG molecules are extremely interesting. Mutations in p53 are found in over 50% of human cancer, while EGCG...

New AI-assisted method could help counter COVID-19 mutations USC researchers have developed a new method to counter emergent mutations of the coronavirus and hasten vaccine development to stop the pathogen responsible for killing thousands of people and ruining the economy. Using artificial intelligence (AI), the research team at the USC Viterbi School of Engineering developed a method to speed the analysis of vaccines and zero in on the best potential preventive medical therapy. The method is easily adaptable to analyze potential mutations of the virus, ensuring the best possible vaccines ar...

Treating severe COVID-19 patients with the anticancer drug bevacizumab may reduce mortality and speed up recovery, according to a small clinical study in Italy and China that was led by researchers at Karolinska Institutet in Sweden between February and April 2020.