A New Weapon Against Cancer: Checkpoint Inhibitors, A Double-Edged Sword
Checkpoint inhibitors, a novel class of anticancer medications, embrace a unique approach to counter tumors.
Source: forbes.com
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LAG-3 protein structure may be the key to unlocking new cancer treatments
A molecular “snapshot” of a protein can be critical to understanding its function. Scientists at Stanford and NYU have published and investigated a new structure of the protein LAG-3 which could enable the development of new cancer treatments.
Source: news-medical.net
Advanced melanoma survival rates improve significantly from 2013 to 2019, Dutch study finds
The change in overall survival (OS) among advanced melanoma patients diagnosed between 2013 and 2021.
Source: news-medical.net
Scientists develop safer CAR T-cell strategy for treating lymphomas
In the treatment of aggressive lymphomas and blood cancer (leukaemia), so-called chimeric antigen receptor T cells (CAR T cells) are increasingly being used.
Source: news-medical.net
Targeting CTLA-4 without colitis induction is gut microbiota dependent
Immune checkpoint inhibitors (ICIs), such as anti-CTLA-4 antibodies, are widely used in cancer immunotherapy. CTLA-4 blockers such as Yervoy (ipilimumab, Bristol Myers Squibb Co.) stimulate antitumoral immune responses, but may also induce toxicity, such as colitis, a common immune-related adverse event that can lead to treatment discontinuation.
Source: bioworld.com