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Clinical Frailty Scores Predict Survival After CAR-T Therapy for B-Cell Lymphoma

Researchers explored the association of clinical frailty assessment with CAR-T outcomes and whether changes in frailty before and after affect outcomes. ....

Anca Prica , Princess Margaret Cancer Centre , Vulnerable Elders Survey , Patient Health Questionnaire , Clinical Frailty Scale , Grip Strength , Gait Speed , Cumulative Illness Rating Scale ,

Continued Maintenance With Obinutuzumab Plus Acalabrutinib/Venetoclax Boosts uMRD Rate in R/R CLL

The undetectable minimal residual disease ate achieved with bendamustine followed by obinutuzumab, acalabrutinib, and venetoclax increased as the regimen was continued as maintenance treatment in patients with relapsed or refractory chronic lymphocytic leukemia. ....

Paula Cramer , Abbvie Inc , International Workshop , Novo Nordisk , International Workshop For Chronic Lymphocytic Leukemia , University Of Cologne , Bristol Myers Squibb , Chronic Lymphocytic Leukemia , Cumulative Illness Rating Scale , Btk Inhibitor , Btk Inhibitor Resistance , International Workshop On Cll , The Phase 2 Cll2 Baag Study Nct03787264 ,

Venetoclax Plus Obinutuzumab Demonstrates Durable Survival Benefit in Treatment-Naïve CLL

Fixed-duration therapy with venetoclax plus obinutuzumab led to 60% reduction in the risk of progression or death compared with chlorambucil plus obinutuzumab, with benefit seen regardless of TP53 or IGHV mutation status, in previously untreated patients with chronic lymphocytic leukemia. ....

Othman Al Sawaf , University Of Cologne , International Conference On Malignant Lymphoma , Division Of Hematology , Intensive Care , Annual International Conference , Cumulative Illness Rating Scale , All Binet , International Conference , Malignant Lymphoma , Chronic Lymphocytic Leukemia ,

CLL: Venetoclax-Obinutuzumab Combo Effective Long Term

Patients with chronic lymphocytic leukemia (CLL) experience long-term progression-free survival benefits with 1 year of venetoclax plus obinutuzumab versus a chemotherapy-based regimen. ....

United States , Williamg Wierda , Othman Al Sawaf , Drug Administration , Study Group , University Of Texas Md Anderson Cancer Center , University Hospital Of Cologne Germany , European Hematology Association , European Hematology , University Hospital , Cancer Center , Cumulative Illness Rating Scale , Chronic Lymphocytic Leukemia , Biologic Therapy , Skin Cancer , Alignant Skin Neoplasm , Lung Cancer , Ung Carcinoma , Ancer Lung , Prostate Carcinoma , Alignant Prostate Neoplasm , Prostate Cancer , Ancer Prostate , Alignant Neoplasia , Tyrosine Kinase Inhibitor , Non Hodgkins Lymphoma ,

AbbVie's VENCLYXTO®/VENCLEXTA® (venetoclax) Continues to Show Sustained Progression-Free Survival (PFS) in Chronic Lymphocytic Leukemia (CLL) Patients

Data from two studies continue to show the long-term efficacy and safety of fixed-duration venetoclax combination regimens across different lines of therapy in. ....

Rheinland Pfalz , Mariana Cota Stirner , Arnonp Kater , John Seymour , Othman Al Sawaf , Venclyxto Sm , Abbvie Deutschland Gmbh Co , Roche Group , Study Group , European Hematology Association , Blood Cancer Press Kit , University Hospital Cologne , Exchange Commission , Annual Congress , Confidence Interval , Hazard Ratio , Integrated Haematology Department , Peter Maccallum Cancer Center , Royal Melbourne Hospital , Cumulative Illness Rating Scale , Crcl This , Allergan Aesthetics , Private Securities Litigation Reform Act , Quarterly Reports , Product Characteristics , Abbvie Deutschland Gmbh ,