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Pflegepaket nimmt Form an: Stabsstelle Pflege startet mit Jänner | Tiroler Tageszeitung Online

Die Praktikerin Kathrin Hörschlager übernimmt die Leitung, der Aufbau erfolgt über ein Tochterinstitut der Tirol Klin...

Stanzertal , Tirol , Austria , John-tyrol , Transactions-of-social-services-stanzertal , Energy-prices , Administrative-body-care , January-tyrol-daily-paper , Country-tyrol , Diploma-nurse , Years-professional-practice , Current-leads

Frontiers | Chagas Disease Drug Discovery in Latin America—A Mini Review of Antiparasitic Agents Explored Between 2010 and 2021

Chagas disease is a neglected tropical disease caused by the protozoan parasite Trypanosoma cruzi that endangers almost 70 million people worldwide. The only two drugs that are currently approved for its treatment, benznidazole and nifurtimox, have controversial efficacy in adults and restricting safety issues, leaving thousands of patients without a suitable treatment. The neglect of Chagas disease is further illustrated by the lack of a robust and diverse drug discovery and development portfolio of new chemical entities, and it is of paramount importance to build a strong research and development network for antichagasic drugs. Focusing on drug discovery programs led by scientists based in Latin America, the main endemic region for this disease, we discuss herein what has been published in the last decade in terms of identification of new antiparasitic drugs to treat Chagas disease, shining a spotlight on the origin, chemical diversity, level of characterization of hits, and strategies used for optimization of lead compounds. Finally, we identify strengths and weaknesses in these drug discovery campaigns and highlight the importance of multidisciplinary collaboration and knowledge sharing.

United-states , El-salvador , America , American , Salvador , Pilar-manzano , Fonseca-murta , Oswaldo-cruz , Van-huijsduijnen , Stardrop-hann , Garcia-bournissen , Van-voorhis

Traum geht in Erfüllung – Belgiens Torkönig Michael Frey steht vor seinem Nati-Debüt

Traum geht in Erfüllung – Belgiens Torkönig Michael Frey steht vor seinem Nati-Debüt
20min.ch - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from 20min.ch Daily Mail and Mail on Sunday newspapers.

Lithuania , Switzerland , Belgium , Belgian , Swiss , League-game , Swiss-national-team , Dream-goes , Current-leads , Belgian-top-scorer , Northern-ireland

Newsblog zur Bundestagswahl 2021 im Oberbergischen Kreis: Sabine Grützmacher vor Einzug in den Bundestag

Newsblog zur Bundestagswahl 2021 im Oberbergischen Kreis: Sabine Grützmacher vor Einzug in den Bundestag
ksta.de - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from ksta.de Daily Mail and Mail on Sunday newspapers.

Gummersbach , Nordrhein-westfalen , Germany , Jagerhof , Party-central , S-either-party , Detail-parliament , Savings-bank , Club-house-garden-plant , Party-her , Party-of-oberbergisches

Newsblog zur Bundestagswahl 2021 im Oberbergischen Kreis: Sabine Grützmacher vor Einzug in den Bundestag

Newsblog zur Bundestagswahl 2021 im Oberbergischen Kreis: Sabine Grützmacher vor Einzug in den Bundestag
ksta.de - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from ksta.de Daily Mail and Mail on Sunday newspapers.

Gummersbach , Nordrhein-westfalen , Germany , Jagerhof , Party-central , S-either-party , Detail-parliament , Savings-bank , Club-house-garden-plant , Party-her , Party-of-oberbergisches

Newsblog zur Bundestagswahl 2021 im Oberbergischen Kreis: Brodesser führt vor Engelmeier

Newsblog zur Bundestagswahl 2021 im Oberbergischen Kreis: Brodesser führt vor Engelmeier
ksta.de - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from ksta.de Daily Mail and Mail on Sunday newspapers.

Gummersbach , Nordrhein-westfalen , Germany , Jagerhof , Party-central , Party-of-oberbergisches , S-either-party , Savings-bank-downtown , Detail-parliament , List-parliament , Savings-bank

Newsblog zur Bundestagswahl 2021 im Oberbergischen Kreis: Brodesser führt vor Engelmeier

Newsblog zur Bundestagswahl 2021 im Oberbergischen Kreis: Brodesser führt vor Engelmeier
ksta.de - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from ksta.de Daily Mail and Mail on Sunday newspapers.

Gummersbach , Nordrhein-westfalen , Germany , Jagerhof , Party-central , S-either-party , Detail-parliament , Savings-bank , Club-house-garden-plant , Party-of-oberbergisches , Savings-bank-downtown

Newsblog zur Bundestagswahl 2021 im Oberbergischen Kreis: Brodesser führt vor Engelmeier

Newsblog zur Bundestagswahl 2021 im Oberbergischen Kreis: Brodesser führt vor Engelmeier
ksta.de - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from ksta.de Daily Mail and Mail on Sunday newspapers.

Gummersbach , Nordrhein-westfalen , Germany , Jagerhof , Party-central , S-either-party , Detail-parliament , Savings-bank , Club-house-garden-plant , Party-of-oberbergisches , Savings-bank-downtown

Newsblog zur Bundestagswahl 2021 im Oberbergischen Kreis: Brodesser liegt mit 10.700 Stimmen in Führung

Newsblog zur Bundestagswahl 2021 im Oberbergischen Kreis: Brodesser liegt mit 10.700 Stimmen in Führung
ksta.de - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from ksta.de Daily Mail and Mail on Sunday newspapers.

Gummersbach , Nordrhein-westfalen , Germany , Jagerhof , Party-central , S-either-party , Detail-parliament , Savings-bank , Club-house-garden-plant , Party-of-oberbergisches , Savings-bank-downtown

Newsblog zur Bundestagswahl 2021 im Oberbergischen Kreis: Brodesser gewinnt mit 11.296 Stimmen Vorsprung

Newsblog zur Bundestagswahl 2021 im Oberbergischen Kreis: Brodesser gewinnt mit 11.296 Stimmen Vorsprung
ksta.de - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from ksta.de Daily Mail and Mail on Sunday newspapers.

Gummersbach , Nordrhein-westfalen , Germany , Jagerhof , Party-central , S-either-party , Detail-parliament , Savings-bank , Club-house-garden-plant , Party-her , Party-of-oberbergisches